Ankang Central Hospital, Department of Hematology and Rheumatology - Shaanxi Province, China.
Rev Assoc Med Bras (1992). 2021 Sep;67(9):1293-1298. doi: 10.1590/1806-9282.20210585.
Our study aimed to explore the potential risk factors for radiological hip joint involvement in patients with ankylosing spondylitis (AS).
This cross-sectional convey collected the clinical data, laboratory indicators, and radiographic data of patients with AS. Radiographic hip joint involvement was defined as a Bath Ankylosing Spondylitis Radiology Hip Index (BASRI-hip) score ≥2. Multivariate logistic regression analyses were conducted to explore the potential risk factors for radiological hip involvement in patients with AS.
Based on BASRI-hip score, all enrolled 386 patients with AS were classified as patients involving with radiological hip joint involvement (BASRI-hip ≥2; n=203) and those without it (BASRI-hip ≤1; n=183). Mean age of enrolled patients with AS were 36.7±11.9 years, and 320 (82.9%) patients were male. Mean course of disease was 10.7±8.3 years, and 349 (90.4%) patients were with a positive HLAB27. Multivariate analyses indicated that Juvenile onset (onset age ≤16 years) (odds ratio [OR]=4.159, 95% confidence interval [CI], 1.779-9.721, p<0.001), body mass index (BMI) <18.5 kg/m2 (OR=1.986, 95%CI 1.187-3.323, p=0.009), continuous nonsteroidal anti-inflammatory drug (NSAID) use (OR=0.351, 95%CI 0.155-0.794, p=0.012), and bone mass below the expected range for age (Z score ≤-2) (OR=2.791, 95%CI 1.456-5.352, p=0.002) were independently associated with radiological hip joint involvement in patients with AS.
The potential risk factors for radiological hip joint involvement were juvenile onset, lower BMI, and bone mass below the expected range for age. Furthermore, continuous NSAID use was the protective factor for radiological hip joint involvement in these population.
本研究旨在探讨强直性脊柱炎（AS）患者影像学髋关节受累的潜在危险因素。
本横断面研究收集了 AS 患者的临床资料、实验室指标和影像学数据。影像学髋关节受累定义为 Bath 强直性脊柱炎放射学髋关节指数（BASRI-hip）评分≥2。采用多变量 logistic 回归分析探讨 AS 患者影像学髋关节受累的潜在危险因素。
根据 BASRI-hip 评分，所有纳入的 386 例 AS 患者被分为影像学髋关节受累（BASRI-hip≥2；n=203）和无髋关节受累（BASRI-hip≤1；n=183）。纳入的 AS 患者平均年龄为 36.7±11.9 岁，320 例（82.9%）为男性。平均病程为 10.7±8.3 年，349 例（90.4%）患者 HLA-B27 阳性。多因素分析表明，发病年龄≤16 岁（发病年龄[OR]=4.159，95%置信区间[CI]，1.779-9.721，p<0.001）、BMI<18.5kg/m2（OR=1.986，95%CI 1.187-3.323，p=0.009）、持续使用非甾体抗炎药（NSAID）（OR=0.351，95%CI 0.155-0.794，p=0.012）和骨量低于年龄预期范围（Z 评分≤-2）（OR=2.791，95%CI 1.456-5.352，p=0.002）与 AS 患者影像学髋关节受累独立相关。
影像学髋关节受累的潜在危险因素包括发病年龄较小、BMI 较低和骨量低于年龄预期范围。此外，持续使用 NSAID 是该人群影像学髋关节受累的保护因素。
