Bogea Eduarda Gomes, Martins Maylla Luanna Barbosa, Carmo Cadidja Dayane Sousa do, Nascimento Joelma Ximenes Prado Teixeira, Arruda Soraia Pinheiro Machado, Ribeiro Cecília Claudia Costa, França Ana Karina Teixeira da Cunha, Silva Antônio Augusto Moura da
Universidade Federal do Maranhão, São Luís, Brasil.
Universidade Estadual do Ceará, Fortaleza, Brasil.
Cad Saude Publica. 2021 Nov 22;37(11):e00212220. doi: 10.1590/0102-311X00212220. eCollection 2021.
The study aimed to analyze factors associated with inflammatory biomarkers in adolescents. This was a cross-sectional study in 391 adolescents 17-18 years of age in public schools in São Luís, Maranhão State, Brazil. Three-stage random cluster sampling was performed in schools, classes, and students. Food consumption was studied with a food frequency questionnaire, and dietary patterns were extracted by principal components factor analysis. Assessment of factors associated with inflammatory biomarkers used structural equation modeling. Latent variables were constructed: socioeconomic status, which included maternal schooling, family income, and economic class; and inflammation, consisting of interleukin-1β, interleukin-6, and interleukin-8. A theoretical model was developed to assess factors associated with inflammatory biomarkers, indicating direct and indirect effects between the latent and observed variables. Three dietary patterns were identified (Western, basic Brazilian, and healthy), with 31% explained variance and the Western pattern with the largest share. No associations were found between the patterns and the latent variable inflammation (standardized coefficients = 0.281; p = 0.002). Extraction of the three patterns evidenced higher consumption of foods high in carbohydrates and fats, which are nutrients associated directly with the increase in chronic noncommunicable diseases. Excess weight was associated with higher levels of inflammatory biomarkers.
该研究旨在分析与青少年炎症生物标志物相关的因素。这是一项针对巴西马拉尼昂州圣路易斯市公立学校391名17 - 18岁青少年的横断面研究。在学校、班级和学生中进行了三阶段随机整群抽样。通过食物频率问卷研究食物消费情况，并通过主成分因子分析提取饮食模式。使用结构方程模型评估与炎症生物标志物相关的因素。构建了潜在变量：社会经济地位，包括母亲受教育程度、家庭收入和经济阶层；以及炎症，由白细胞介素 - 1β、白细胞介素 - 6和白细胞介素 - 8组成。开发了一个理论模型来评估与炎症生物标志物相关的因素，表明潜在变量和观察变量之间的直接和间接影响。确定了三种饮食模式（西方模式、巴西基本模式和健康模式），解释方差为31%，其中西方模式占比最大。未发现这些模式与潜在变量炎症之间存在关联（标准化系数 = 0.281；p = 0.002）。三种模式的提取表明，碳水化合物和脂肪含量高的食物消费量较高，这些营养素与慢性非传染性疾病的增加直接相关。超重与较高水平的炎症生物标志物相关。
