Office of Research Innovation and Commercialization Department, Lahore Garrison University, Lahore, Pakistan.
Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), H-12, Islamabad 44000, Pakistan.
Cell Mol Biol (Noisy-le-grand). 2021 Aug 15;67(2):33-43. doi: 10.14715/cmb/2021.67.2.6.
Notch signaling is an evolutionary conserved pathway that plays a central role in development and differentiation of eukaryotic cells. It has been well documented that Notch signaling is inevitable for neuronal cell growth and homeostasis. It regulates process of differentiation from early embryonic stages to fully developed brain. To achieve this streamlined development of neuronal cells, a number of cellular processes are being orchestrated by the Notch signaling. Abrogated Notch signaling is related to several brain tumors, including glioblastomas. On the other hand, microRNAs are small molecules that play decisive role in mediating and modulating Notch signaling. This review discusses the crucial role of Notch signaling in development of nervous system and how this versatile pathway interplay with microRNAs in glioblastoma. This review sheds light on interplay between abrogated Notch signaling and miRNAs in the regulation of neuronal differentiation with special focus on miRNAs mediated regulation of tumorigenesis in glioblastoma. Furthermore, it discusses different aspects of neurogenesis modulated by the Notch signaling that could be exploited for the identification of new diagnostic tools and therapies for the treatment of glioblastoma.
Notch 信号通路是一种进化上保守的途径，在真核细胞的发育和分化中起着核心作用。已有充分的文献证明，Notch 信号通路对于神经元细胞的生长和稳态是必不可少的。它调节着从早期胚胎阶段到完全发育的大脑的分化过程。为了实现神经元细胞的这种流线型发育，许多细胞过程都由 Notch 信号通路来协调。Notch 信号通路的中断与包括神经胶质瘤在内的几种脑瘤有关。另一方面，microRNAs 是在介导和调节 Notch 信号通路中起决定性作用的小分子。这篇综述讨论了 Notch 信号通路在神经系统发育中的关键作用，以及这种多功能通路如何与神经胶质瘤中的 microRNAs 相互作用。这篇综述阐明了 Notch 信号通路中断和 microRNAs 在神经元分化调节中的相互作用，特别关注 microRNAs 介导的神经胶质瘤中的肿瘤发生的调节。此外，它还讨论了 Notch 信号通路调节的神经发生的不同方面，可以利用这些方面来识别新的诊断工具和治疗神经胶质瘤的方法。
