Stoyanov George S, Dzhenkov Deyan, Petkova Lilyana, Velkova Deyana, Sapundzhiev Nikolay, Ghenev Peter
Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University-Varna "Prof. Dr. Paraskev Stoyanov", 9002, Varna, Bulgaria.
Department of Neurosurgery and ENT Diseases, Division of ENT Diseases, Faculty of Medicine, Medical University-Varna "Prof. Dr. Paraskev Stoyanov", Varna, Bulgaria.
Wien Klin Wochenschr. 2022 Mar;134(5-6):237-242. doi: 10.1007/s00508-021-01969-x. Epub 2021 Nov 24.
Frank's sign (FS) was described in 1973 as an auricular marker for cardiovascular disease presenting as a crease of the auricular lobule. Since its first clinical description, there have been multiple studies underlining the role of FS in a myriad of conditions, such as atherosclerosis, hypertension, cerebrovascular disease, peripheral artery disease, metabolic diseases as well as studies looking at physiological differences in the auricular shape that may mimic FS; however, a complex study to comprehensively analyze the clinical, gross, and histological findings of patients with FS has not yet been performed. Most studies focused on a specific system, mechanism of disease entry. This short review tries to summarize the current knowledge of FS in relation to diseases as well as its clinical classification, histology, and association with the recently described paired ear creases of the helix, as an attempt to reveal the dubious role of FS as a possible prognostic and predictive marker.
弗兰克征（FS）于1973年被描述为心血管疾病的一种耳部标志，表现为耳垂出现褶皱。自首次临床描述以来，已有多项研究强调了FS在众多病症中的作用，如动脉粥样硬化、高血压、脑血管疾病、外周动脉疾病、代谢疾病，以及研究耳部形状可能类似FS的生理差异；然而，尚未进行一项全面分析FS患者临床、大体和组织学表现的综合研究。大多数研究聚焦于特定系统、疾病发病机制。本简短综述试图总结目前关于FS与疾病相关的知识，以及其临床分类、组织学，以及与最近描述的耳轮成对褶皱的关联，旨在揭示FS作为可能的预后和预测标志物的可疑作用。
