耳垂皱褶（弗兰克征）与异常踝臂指数测定之间的关联与年龄相关：一项基于人群的研究。
The Association between Earlobe Crease (Frank's Sign) and Abnormal Ankle-Brachial Index Determination Is Related to Age: A Population-Based Study.
作者信息
Del Brutto Oscar H, Mera Robertino M, Costa Aldo F, Zambrano Mauricio, Sedler Mark J
机构信息
School of Medicine, Universidad Espíritu Santo-Ecuador, Guayaquil, Ecuador.
Vanderbilt University Medical Center, Nashville, TN, USA.
出版信息
Int J Vasc Med. 2018 Sep 2;2018:4735731. doi: 10.1155/2018/4735731. eCollection 2018.
BACKGROUND
Information on the association between earlobe crease (ELC) and peripheral artery disease is limited. We assessed this association in community-dwelling older adults.
STUDY DESIGN
A total of 294 Atahualpa residents aged ≥60 years were enrolled. ELC were visually identified by two raters. The ankle-brachial index (ABI), used as a surrogate of peripheral artery disease, was categorized using American Heart Association criteria. Using logistic regression and probability models, adjusted for demographics and cardiovascular risk factors, we assessed the relationship between ELC and abnormal ABI determinations, as well as the influence of age on this association.
RESULTS
ELC was identified in 141 (48%) individuals, and abnormal ABI determination was carried out in 56 (19%). The association between ELC and abnormal ABI was nonsignificant in logistic regression and probability models with individuals stratified according to their median age.
CONCLUSIONS
The association between ELC and abnormal ABI determinations is probably attenuated by the high prevalence of both conditions in older persons. ELC might not be useful for identifying candidates for ABI determination.
背景
关于耳垂褶皱（ELC）与外周动脉疾病之间关联的信息有限。我们在社区居住的老年人中评估了这种关联。
研究设计
共纳入了294名年龄≥60岁的阿塔瓦尔帕居民。由两名评估者通过肉眼识别耳垂褶皱。作为外周动脉疾病替代指标的踝臂指数（ABI），根据美国心脏协会标准进行分类。使用逻辑回归和概率模型，对人口统计学和心血管危险因素进行校正后，我们评估了耳垂褶皱与异常ABI测定之间的关系，以及年龄对这种关联的影响。
结果
141名（48%）个体存在耳垂褶皱，56名（19%）进行了异常ABI测定。在根据年龄中位数分层的个体的逻辑回归和概率模型中，耳垂褶皱与异常ABI之间的关联不显著。
结论
在老年人中，这两种情况的高患病率可能减弱了耳垂褶皱与异常ABI测定之间的关联。耳垂褶皱可能无助于识别进行ABI测定的候选者。
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