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[基层医疗中自杀行为的简短筛查工具——系统评价]

[Short screener for suicidal behaviour in primary care - a systematic review].

作者信息

Lukaschek Karoline, Frank Milena, Halfter Kathrin, Schneider Antonius, Gensichen Jochen

机构信息

- Institut für Allgemeinmedizin -, Campus Innenstadt d. LMU München, Pettenkoferstraße 8 a, 80336, München, Germany.

Institut für Allgemeinmedizin, Universitätsklinik der Ludwig-Maximilians-Universität München, München, Germany.

出版信息

MMW Fortschr Med. 2021 Dec;163(Suppl 6):9-18. doi: 10.1007/s15006-021-0507-2.

Abstract

BACKGROUND

We summarize the available studies reporting diagnostic accuracy of brief instruments for suicidal behaviour in primary care.

METHOD

Databases MEDLINE, EMBASE, PsychINFO, PSYNDEX, and Cochrane Library were searched without any time constraints. Risk of bias and applicability concerns were assessed using the QUADAS-2 tool. The certainty of evidence was rated via GRADEpro. We included studies on primary care patients or participants from the general population. Suicidal behaviour was the defined target condition. With respect to the applicability in a primary care setting we included only studies assessing brief screening instruments; a brief instrument was defined as having no more than 12 items. We assessed sensitivity, specificity, and positive and negative predictive value.

RESULTS

A total of 12,460 studies were identified; of those, n = 7 fulfilled all strong criteria and were included. The range of sensitivity was 0.26-1.00, specificity was 0.64-0.99, positive predictive value 0.06-0.91, negative predictive value 0.83-1.00. Risk of bias was rated moderate and concerns regarding applicability acceptable. A required sensitivity of at least 0.80 and specificity of 0.50 with a moderate to high GRADE rating was achieved by 8 of 11 index tests.

CONCLUSIONS

Brief screening instruments can support ruling-out suicidality, but are less suitable for ruling-in. They may support general practitioners in an initial assessment, but in case of a positive test result, a valid diagnostic assessment should be done by a structured clinical interview.

摘要

背景

我们总结了现有研究,这些研究报告了基层医疗中用于自杀行为的简短工具的诊断准确性。

方法

对MEDLINE、EMBASE、PsychINFO、PSYNDEX和Cochrane图书馆数据库进行了无时间限制的检索。使用QUADAS-2工具评估偏倚风险和适用性问题。通过GRADEpro对证据的确定性进行评级。我们纳入了关于基层医疗患者或普通人群参与者的研究。自杀行为是定义的目标状况。关于在基层医疗环境中的适用性,我们仅纳入了评估简短筛查工具的研究;简短工具被定义为不超过12个项目。我们评估了敏感性、特异性以及阳性和阴性预测值。

结果

共识别出12460项研究;其中,n = 7项符合所有严格标准并被纳入。敏感性范围为0.26 - 1.00,特异性为0.64 - 0.99,阳性预测值为0.06 - 0.91,阴性预测值为0.83 - 1.00。偏倚风险被评为中等,适用性问题可接受。11项指标测试中的8项达到了至少0.80的敏感性要求和0.50的特异性要求,且GRADE评级为中到高。

结论

简短筛查工具可辅助排除自杀倾向,但不太适合确诊。它们可在初始评估中为全科医生提供支持,但如果检测结果为阳性,应由结构化临床访谈进行有效的诊断评估。

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