Department of Infectious Disease, Shengjing Hospital of China Medical University, No.39 of Huaxiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, China.
Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, Liaoning Province, China.
Daru. 2022 Jun;30(1):153-157. doi: 10.1007/s40199-021-00420-w. Epub 2021 Nov 24.
Glucocorticoids are used as a first-line treatment for severe alcoholic hepatitis, and albumin reduces both the number of hospitalizations and mortality in patients with decompensated cirrhosis. However, for acute-on-chronic liver failure (ACLF), there is no definitive evidence that glucocorticoid therapy is beneficial. In this case report, we describe a male patient who developed into ACLF based on alcoholic cirrhosis, whose symptoms and clinical indicators continued to deteriorate after initial symptomatic treatment. The patient's condition gradually improved after low-dose glucocorticoid therapy, and long-term albumin supplementation resulted in a satisfactory outcome.
糖皮质激素被用作重症酒精性肝炎的一线治疗药物，白蛋白可降低失代偿性肝硬化患者的住院次数和死亡率。然而，对于慢加急性肝衰竭（ACLF），尚无明确证据表明糖皮质激素治疗有益。在本病例报告中，我们描述了一位男性患者，他因酒精性肝硬化发展为 ACLF，在初始对症治疗后症状和临床指标持续恶化。患者在接受小剂量糖皮质激素治疗后病情逐渐改善，长期白蛋白补充治疗也取得了满意的效果。
