维生素C缺乏和低亚麻酸摄入量与血压升高相关：库奥皮奥缺血性心脏病危险因素研究。

Vitamin C deficiency and low linolenate intake associated with elevated blood pressure: the Kuopio Ischaemic Heart Disease Risk Factor Study.

作者信息

Salonen J T, Salonen R, Ihanainen M, Parviainen M, Seppänen R, Seppänen K, Rauramaa R

机构信息

Department of Community Health, University of Kuopio, Finland.

出版信息

J Hypertens Suppl. 1987 Dec;5(5):S521-4.

PMID:3481820

Abstract

We investigated the association of dietary fatty acids and plasma antioxidative vitamins with blood pressure in 722 eastern Finnish men aged 54 years, examined in the Kuopio Ischaemic Heart Disease Risk Factor Study in 1984-1986, who had no known hypertension nor any cerebrovascular disease. Allowing for the major anthropometric, dietary, medical and psychological determinants of blood pressure in a multivariate regression analysis, plasma ascorbic acid concentration had a moderate, independent inverse association (P less than 0.0001) and the estimated dietary intake of linolenic acid an inverse (P = 0.026) independent association with mean resting blood pressure. The marked elevation of blood pressure at the lowest levels of plasma vitamin C concentration supports the hypothesis of the role of antioxidants in the aetiology of hypertension.

摘要

我们在1984年至1986年于库奥皮奥进行的缺血性心脏病危险因素研究中，对722名年龄54岁、无已知高血压及任何脑血管疾病的芬兰东部男性，研究了膳食脂肪酸和血浆抗氧化维生素与血压的关联。在多变量回归分析中，考虑到血压的主要人体测量学、膳食、医学和心理决定因素，血浆抗坏血酸浓度与平均静息血压呈中度独立负相关（P<0.0001），估计的膳食亚麻酸摄入量与平均静息血压呈独立负相关（P = 0.026）。血浆维生素C浓度处于最低水平时血压显著升高，支持了抗氧化剂在高血压病因学中起作用的假说。