Albert Christine M, Oh Kyungwon, Whang William, Manson JoAnn E, Chae Claudia U, Stampfer Meir J, Willett Walter C, Hu Frank B
Center for Arrhythmia Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215-1204, USA.
Circulation. 2005 Nov 22;112(21):3232-8. doi: 10.1161/CIRCULATIONAHA.105.572008.
Alpha-linolenic acid, an intermediate-chain n-3 fatty acid found primarily in plants, may decrease the risk of fatal coronary heart disease (CHD) through a reduction in fatal ventricular arrhythmias and sudden cardiac death (SCD).
We prospectively examined the association between dietary intake of alpha-linolenic acid assessed via updated food-frequency questionnaires and the risk of SCD, other fatal CHD, and nonfatal myocardial infarction (MI) among 76,763 women participating in the Nurses' Health Study who were free from cancer and completed a dietary questionnaire at baseline in 1984. During 18 years of follow-up, we identified 206 SCDs, 641 other CHD deaths, and 1604 nonfatal MIs. After controlling for coronary risk factors and other fatty acids, including long-chain n-3 fatty acids, the intake of alpha-linolenic acid was inversely associated with the risk of SCD (P for trend, 0.02) but not with the risk of other fatal CHD or nonfatal MI. Compared with women in the lowest quintile of alpha-linolenic acid intake, those in the highest 2 quintiles had a 38% to 40% lower SCD risk. This inverse relation with SCD risk was linear and remained significant even among women with high intakes of long-chain n-3 fatty acids.
These prospective data suggest that increasing dietary intake of alpha-linolenic acid may reduce the risk of SCD but not other types of fatal CHD or nonfatal MI in women. The specificity of the association between alpha-linolenic acid and SCD supports the hypothesis that these n-3 fatty acids may have antiarrhythmic properties.
α-亚麻酸是一种主要存在于植物中的中链n-3脂肪酸，可能通过减少致命性室性心律失常和心源性猝死（SCD）来降低致命性冠心病（CHD）的风险。
我们前瞻性地研究了通过更新后的食物频率问卷评估的α-亚麻酸饮食摄入量与76763名参与护士健康研究的女性发生SCD、其他致命性CHD和非致命性心肌梗死（MI）风险之间的关联。这些女性无癌症，于1984年基线时完成了饮食问卷。在18年的随访期间，我们确定了206例SCD、641例其他CHD死亡和1604例非致命性MI。在控制了冠状动脉危险因素和其他脂肪酸（包括长链n-3脂肪酸）后，α-亚麻酸的摄入量与SCD风险呈负相关（趋势P值为0.02），但与其他致命性CHD或非致命性MI的风险无关。与α-亚麻酸摄入量最低五分位的女性相比，最高两个五分位的女性SCD风险降低了38%至40%。这种与SCD风险的负相关关系是线性的，即使在长链n-3脂肪酸摄入量高的女性中也仍然显著。
这些前瞻性数据表明，增加α-亚麻酸的饮食摄入量可能会降低女性SCD的风险，但不会降低其他类型的致命性CHD或非致命性MI的风险。α-亚麻酸与SCD之间关联的特异性支持了这些n-3脂肪酸可能具有抗心律失常特性的假说。
