Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
ORL J Otorhinolaryngol Relat Spec. 2022;84(4):296-301. doi: 10.1159/000518660. Epub 2021 Sep 27.
Alternatives to positive airway pressure therapy, including surgery, represent an important area of research. Specifically, predictors of response to surgical therapy remain underdeveloped. Drug-induced sleep endoscopy (DISE) holds promise as a diagnostic tool to identify patient-specific causes of airway collapse. Herein, we present a novel, standardized approach which combines anatomic and physiologic measurements during DISE. Our DISE platform measures airflow, airway compliance, airway collapsibility, and structural drivers of collapse. Taken together, these inputs provide a comprehensive framework to further inform the surgeon in providing personalized care of the patient with obstructive sleep apnea.
除了正压通气疗法（positive airway pressure therapy）以外，其他的治疗方法（包括手术）也是研究的重点。特别是，手术治疗的反应预测因素仍有待进一步研究。药物诱导睡眠内镜（Drug-induced sleep endoscopy，DISE）有望成为一种诊断工具，用以识别导致气道塌陷的特定原因。在此，我们提出了一种新的、标准化的方法，该方法在 DISE 过程中结合了解剖学和生理学测量。我们的 DISE 平台可以测量气流、气道顺应性、气道塌陷性和导致塌陷的结构驱动因素。总的来说，这些信息为外科医生为阻塞性睡眠呼吸暂停患者提供个性化护理提供了一个全面的框架。
