口服氧氟沙星后其向抽吸水疱液中的转移

[Transfer of ofloxacin into suction blister fluid after its oral administration].

作者信息

Aoyama H, Sugiyama H, Ishii T, Kawauchi T, Kasuya T, Nishizaki A, Okuda J

机构信息

Department of Plastic Surgery, Aichi Medical University.

出版信息

Jpn J Antibiot. 1987 Nov;40(11):1937-40.

PMID:3481837

Abstract

After oral administration of 300 mg of ofloxacin (OFLX), the concentration of OFLX in serum peaked at 2 hours and reached 2.88 +/- 0.62 micrograms/ml (mean +/- S.D.). In the fluid of dermal blisters produced by suction, the peak value was 1.74 +/- 0.88 micrograms/ml at 4 hours. Pharmacokinetically, Cmax (maximum concentration), Tmax (time of maximum concentration), Ka (absorption rate constant) and AUC0-8hrs. (area under the concentration-time curve) were calculated as 2.65 micrograms/ml, 2.07 hours, 0.79 hr-1 and 14.5 micrograms.hr/ml in serum, and 1.59 micrograms/ml, 4.49 hours, 0.27 hr-1 and 10.1 micrograms.hr/ml, respectively. Therapeutic AUC (area under the curve above minimum effective concentration) were also calculated as 13.3 micrograms.hr/ml (0.14-12.4 hours) in serum, and 11.5 micrograms.hr/ml (0.42-17.3 hours).

摘要

口服300毫克氧氟沙星（OFLX）后，血清中氧氟沙星浓度在2小时达到峰值，为2.88±0.62微克/毫升（均值±标准差）。在抽吸产生的皮肤水疱液中，4小时时峰值为1.74±0.88微克/毫升。从药代动力学来看，血清中的Cmax（最大浓度）、Tmax（最大浓度时间）、Ka（吸收速率常数）和AUC0 - 8hrs（浓度 - 时间曲线下面积）分别计算为2.65微克/毫升、2.07小时、0.79小时⁻¹和14.5微克·小时/毫升，皮肤水疱液中分别为1.59微克/毫升、4.49小时、0.27小时⁻¹和10.1微克·小时/毫升。血清中治疗性AUC（高于最低有效浓度的曲线下面积）计算为13.3微克·小时/毫升（0.14 - 12.4小时），皮肤水疱液中为11.5微克·小时/毫升（0.42 - 17.3小时）。