MD. Department of General Surgery - Basaksehir Cam and Sakura City Hospital - Istanbul, Turkey.
MD. Department of General Surgery - Adana City Research and Training Center - Saglik Bilimleri University - Adana, Turkey.
Acta Cir Bras. 2021 Oct 25;36(9):e360902. doi: 10.1590/ACB360902. eCollection 2021.
To investigate experimentally the effects of Tropifexor, a farnesoid X receptor agonist, on liver injury in rats with obstructive jaundice.
Forty healthy Wistar albino female rats were divided randomly in selected groups. These groups were the sham group, control group, vehicle solution group, Ursodeoxycholic acid group and Tropifexor group. Experimental obstructive jaundice was created in all groups, except the sham one. In the blood samples obtained, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin and direct bilirubin levels were established and recorded. Additionally, liver malondialdehyde, myeloperoxidase and catalase enzyme activity in the tissue samples were studied. Histopathological analysis was also performed.
No statistical difference was found between the control group and the Tropifexor group when AST, ALT and ALP values were compared. However, it was found that the Tropifexor group had statistically significant decreases in the values of GGT, total bilirubin and direct bilirubin (p < 0.05). Additionally, Tropifexor decreased the median values of malondialdehyde and myeloperoxidase, but this difference was not statistically significant compared to the control group. Finally, the Tropifexor group was statistically significant in recurring histopathological liver damage indicators (p < 0.05).
Tropifexor reduced liver damage due to obstructive jaundice.
实验研究法尼醇 X 受体激动剂 Tropifexor 对梗阻性黄疸大鼠肝损伤的影响。
将 40 只健康雌性 Wistar 白化大鼠随机分为选定的组。这些组包括假手术组、对照组、载体溶液组、熊去氧胆酸组和 Tropifexor 组。除假手术组外，所有组均建立实验性梗阻性黄疸。在获得的血液样本中，测定并记录天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、碱性磷酸酶（ALP）、γ-谷氨酰转移酶（GGT）、总胆红素和直接胆红素水平。此外，还研究了组织样本中的肝丙二醛、髓过氧化物酶和过氧化氢酶活性。还进行了组织病理学分析。
当比较 AST、ALT 和 ALP 值时，对照组和 Tropifexor 组之间没有统计学差异。然而，发现 Tropifexor 组的 GGT、总胆红素和直接胆红素值具有统计学显著降低（p < 0.05）。此外，Tropifexor 降低了丙二醛和髓过氧化物酶的中位数，但与对照组相比，这种差异没有统计学意义。最后，Tropifexor 组在复发性肝组织损伤指标方面具有统计学意义（p < 0.05）。
Tropifexor 减轻了梗阻性黄疸引起的肝损伤。
