Li Siyun, Fear Elise, Curiel Laura
Department of Electrical and Software Engineering, Schulich School of Engineering, University of Calgary, Alberta, Canada.
Phys Med Biol. 2021 Dec 13;66(24). doi: 10.1088/1361-6560/ac3d18.
We present a new formulation for a breast tissue-mimicking phantom for combined microwave and ultrasound imaging to assist breast cancer detection. Formulations based on coconut oil, canola oil, agar and glass beads were used to mimic skin and fat tissues. First, 36 recipes were fabricated, and properties were measured to determine the relationship and possible interaction between ingredients with the ultrasound and microwave properties. Based on these results, the formulae were developed to mimic different tissues found in breast, including skin, fat, fibroglandular, and tumour tissues. All phantoms contained a base of agar and glass beads at different proportions depending on the tissue mimicked. Tumour and fibroglandular tissues were best mimicked by adding polyvinylpyrrolidone (PVP), while using coconut oil for skin and canola oil for fat produced the best results. Five final phantoms with different internal structures were fabricated and imaged using B-mode ultrasound and a microwave transmission system. Microwave permittivity maps were obtained from the microwave system and compared to ultrasound images. The structure and composition of the phantoms were all confirmed through this microwave and ultrasound imaging.
我们提出了一种用于联合微波和超声成像的新型乳腺组织模拟体模配方，以辅助乳腺癌检测。基于椰子油、菜籽油、琼脂和玻璃珠的配方被用于模拟皮肤和脂肪组织。首先，制备了36种配方，并测量其特性，以确定成分与超声和微波特性之间的关系及可能的相互作用。基于这些结果，开发了模拟乳腺中不同组织（包括皮肤、脂肪、纤维腺组织和肿瘤组织）的配方。所有体模都含有琼脂和玻璃珠的基底，其比例根据所模拟的组织而不同。通过添加聚乙烯吡咯烷酮（PVP）能最好地模拟肿瘤和纤维腺组织，而用椰子油模拟皮肤、菜籽油模拟脂肪则能产生最佳效果。制作了五个具有不同内部结构的最终体模，并使用B型超声和微波传输系统进行成像。从微波系统获得微波介电常数图，并与超声图像进行比较。通过这种微波和超声成像，证实了体模的结构和组成。
