Zhang X F, Liu F, Liu W P, Ye X M, Cui B Y, Wang H J
National Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Shaanxi Provincial Centre for Disease Control and Prevention, Xi'an 710054, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Nov 10;42(11):1955-1961. doi: 10.3760/cma.j.cn112338-20200930-01210.
To explore the relationship between sleep duration and depressive symptoms in middle-aged and elderly people. A total of 11 931 middle-aged and elderly people aged ≥55 years who participated in the baseline survey of the "Community Cohort Study of Specialized Nervous System Diseases" in China from 2018 to 2019 were selected to obtain basic information about their lifestyle, food intake frequency, disease history, sleep duration. The body height and weight were measured, and body mass index (BMI) were calculated. The subjects with depressive symptoms were screened with the Geriatric Depression Scale (GDS-30). Restricted cubic spline model and multivariate logistic regression model were used to analyze the relationship between sleep duration and depressive symptoms. Among the middle-aged and elderly people aged ≥55 years, 17.79% reported sleep duration less than 7 hours, 16.84% reported that their sleep duration ≥9 hours, and the detection rate of depression symptoms was 7.95%. After adjusting for factors such as region, age, gender, the restricted cubic spline results showed the U-shaped relationship between sleep duration and the risk for depressive symptoms, the results of multivariate logistic regression analysis showed that the risk for depressive symptom in middle-aged and elderly people aged ≥55 years with sleep duration ≤5 hours, 6 hours, and ≥9 hours were 1.749(95%:1.279-2.392), 1.284(95%:1.021-1.615) and 1.260(95%:1.033-1.538) times higher compared with the counterparts with sleep duration 7-8 hours, the risk for depressive symptom in women with sleep duration ≤5 hours, 6 hours and ≥9 hours were 2.115 (95%:1.473-3.038), 1.605(95%:1.213-2.123) and 1.313(95%:1.011-1.705) times higher, respectively, compared with counterparts with sleep duration 7-8 hours, the risk for depressive symptoms in 55-64-year-old middle-aged and elderly people with sleep duration ≤5 hours and ≥9 hours were 1.806 (95%:1.014-3.217) and 1.478 (95%:1.060-2.061) times higher compared with counterparts with sleep duration 7-8 hours, and the risk for depressive symptoms in elderly people aged 65-74 years with sleep duration ≤5 hours was 2.112 (95%:1.327-3.361)times higher compared with counterparts with sleep duration 7-8 hours, the differences were all significant (<0.05). There was no statistically significant association between sleep duration and depressive symptoms in men and in elderly people aged ≥75 years (>0.05). Insufficient or prolonged sleep was independently associated with depressive symptoms in middle-aged and elderly people, showing a U-shaped relationship, especially in women and in middle-aged and elderly people aged 55-64 years.
探讨中老年人群睡眠时间与抑郁症状之间的关系。选取2018年至2019年参加中国“神经系统专科疾病社区队列研究”基线调查的11931名年龄≥55岁的中老年人群，获取其生活方式、食物摄入频率、病史、睡眠时间等基本信息。测量身高和体重，并计算体重指数（BMI）。采用老年抑郁量表（GDS-30）对有抑郁症状的受试者进行筛查。运用受限立方样条模型和多因素logistic回归模型分析睡眠时间与抑郁症状之间的关系。在年龄≥55岁的中老年人群中，17.79%的人报告睡眠时间少于7小时，16.84%的人报告睡眠时间≥9小时，抑郁症状检出率为7.95%。在调整地区、年龄、性别等因素后，受限立方样条结果显示睡眠时间与抑郁症状风险呈U型关系，多因素logistic回归分析结果显示，睡眠时间≤5小时、6小时和≥9小时的≥55岁中老年人群抑郁症状风险分别是睡眠时间为7-8小时人群的1.749（95%：1.279-2.392）、1.284（95%：1.021-1.615）和1.260（95%：1.033-1.538）倍；睡眠时间≤5小时、6小时和≥9小时的女性抑郁症状风险分别是睡眠时间为7-8小时女性的2.115（95%：1.473-3.038）、1.605（95%：1.213-2.123）和1.313（95%：1.011-1.705）倍；55-64岁中老年人群中，睡眠时间≤5小时和≥9小时的抑郁症状风险分别是睡眠时间为7-8小时人群的1.806（95%：1.014-3.217）和1.478（95%：1.060-2.061）倍；65-74岁老年人中，睡眠时间≤5小时的抑郁症状风险是睡眠时间为7-8小时人群的2.112（95%：1.327-3.361）倍，差异均有统计学意义（<0.0）。男性及年龄≥75岁老年人的睡眠时间与抑郁症状之间无统计学意义的关联（>0.05）。睡眠不足或过长与中老年人群抑郁症状独立相关，呈U型关系，尤其在女性及55-64岁的中老年人群中。
