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中国老年人在新冠疫情之前及期间抑郁症患病率的差异:一项系统评价与荟萃分析

Differences in depression prevalence among older adults in China before and during the COVID-19 pandemic: a systematic review and meta-analysis.

作者信息

Zhao Xin, Du Xiaojing, Bai Shuliang, Zheng Pianpian, Zhou Xun, Wang Zhenjie

机构信息

Nanjing University, Nanjing, China.

Xi'an Jiaotong University, Xi'an, China.

出版信息

PeerJ. 2025 Apr 11;13:e19251. doi: 10.7717/peerj.19251. eCollection 2025.

Abstract

OBJECTIVE

Changes in the prevalence of depression during the COVID-19 (Coronavirus disease 2019) pandemic among older adults in China have not been systematically evaluated. We aimed to systematically summarize existing evidence to conduct a meta-analysis to quantify changes in the prevalence of depression before and during the COVID-19 pandemic.

METHODS

The PubMed, Web of Science, Scopus, Embase, PsycINFO, China National Knowledge Infrastructure (CNKI), WangFang Data, CQVIP, and China Biology Medicine disc (CBMdisc) databases were searched from January 1, 2017, to November 20, 2024. Studies reporting the prevalence of depression among Chinese individuals aged 60 or older using validated diagnostic tools were included. A random-effects model was applied to estimate pooled prevalence, with subgroup analyses performed by demographic and socio-economic factors. Relative risks (RR) were calculated to compare prevalence across different pandemic stages.

RESULTS

A total of 101 studies involving 264,758 participants were included. The pooled prevalence of depression among older adults was 25.8% (95% CI [21.7-29.9]) from 2017-2019 and 23.8% (95% CI [19.8-27.8]) from 2020-2023. During the early pandemic stage (January-April 2020), prevalence significantly decreased (RR = 0.849,  < .001) but increased in later stages, reaching 24.4% by 2021-2023. The prevalence of depression among older adults during the COVID-19 pandemic showed a significant increasing trend (  < .001). Subgroup analyses revealed higher prevalence among females, rural residents, individuals with lower education levels, and those living alone.

CONCLUSION

Depression prevalence among older adults in China decreased during the early pandemic response but showed an increasing trend over time, reflecting the complex mental health impact of prolonged public health measures. Effective interventions are needed to address the specific needs of vulnerable subgroups during and beyond public health crises.

摘要

目的

中国老年人在2019年冠状病毒病(COVID-19)大流行期间抑郁症患病率的变化尚未得到系统评估。我们旨在系统总结现有证据,进行荟萃分析,以量化COVID-19大流行之前和期间抑郁症患病率的变化。

方法

检索了2017年1月1日至2024年11月20日期间的PubMed、Web of Science、Scopus、Embase、PsycINFO、中国知网(CNKI)、万方数据、维普资讯和中国生物医学文献数据库(CBMdisc)。纳入使用经过验证的诊断工具报告60岁及以上中国人群抑郁症患病率的研究。应用随机效应模型估计合并患病率,并按人口统计学和社会经济因素进行亚组分析。计算相对风险(RR)以比较不同大流行阶段的患病率。

结果

共纳入101项研究,涉及264,758名参与者。2017 - 2019年老年人抑郁症的合并患病率为25.8%(95%置信区间[21.7 - 29.9]),2020 - 2023年为23.8%(95%置信区间[19.8 - 27.8])。在大流行早期阶段(2020年1月至4月),患病率显著下降(RR = 0.849,P <.001),但在后期有所上升,到2021 - 2023年达到24.4%。COVID-19大流行期间老年人抑郁症患病率呈显著上升趋势(P <.001)。亚组分析显示,女性、农村居民、教育程度较低者以及独居者的患病率较高。

结论

中国老年人抑郁症患病率在大流行早期应对阶段有所下降,但随时间呈上升趋势,反映了长期公共卫生措施对心理健康的复杂影响。需要采取有效的干预措施,以满足公共卫生危机期间及之后弱势群体的特殊需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2908/11995894/dc1bf585e874/peerj-13-19251-g001.jpg

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