弯曲菌属简明亚种胃炎在胃活检中伪装成幽门螺杆菌。

Campylobacter concisus gastritis masquerading as Helicobacter pylori on gastric biopsy.

机构信息

Department of Pathology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Department of Medical Microbiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

出版信息

Helicobacter. 2022 Apr;27(2):e12864. doi: 10.1111/hel.12864. Epub 2021 Nov 24.

DOI:10.1111/hel.12864

PMID:34820966

Abstract

OBJECTIVE

Campylobacter concisus is a Gram-negative rod closely related to Helicobacter pylori. We sought to identify gastric biopsies positive for C. concisus that had been misdiagnosed as H. pylori gastritis in our routine surgical pathology practice.

MATERIALS AND METHODS

We performed a retrospective review of gastric biopsies in our regional microbiology and pathology electronic records to identify cases that were submitted for H. pylori testing in which C. consicus was identified on culture and how many had concurrent biopsies sent to pathology for histologic assessment over a two-year period (2017-2018). Pathologic findings in the gastric biopsies were reviewed and immunohistochemical staining for H. pylori was performed.

RESULTS

50 of 2191 gastric biopsy specimens submitted to microbiology in 2017-18 grew C. concisus (2.3%), compared to 168 in which H. pylori was identified (7.7%). Twenty-eight cases had concurrent histology. A total of four cases (three from 2017 and one from 2018) demonstrated organisms morphologically identical to H. pylori in the H&E sections, of which all were H. pylori immunoreactive.

CONCLUSIONS

Our case series is the first to demonstrate that C. concisus can mimic H. pylori gastritis in routine biopsy pathology.

摘要

目的

空肠弯曲菌是一种与幽门螺杆菌密切相关的革兰氏阴性杆菌。我们试图在常规外科病理学实践中鉴定出被误诊为幽门螺杆菌胃炎的空肠弯曲菌阳性胃活检标本。

材料和方法

我们对本地区微生物学和病理学电子记录中的胃活检进行了回顾性分析，以确定在两年期间（2017-2018 年），有多少例因幽门螺杆菌检测而提交的病例中培养出空肠弯曲菌，以及有多少例同时将活检标本送往病理科进行组织学评估。回顾了胃活检的病理发现，并进行了幽门螺杆菌的免疫组织化学染色。

结果

2017-18 年，50 例（2.3%）送检微生物学的 2191 例胃活检标本中生长有空肠弯曲菌，而 168 例中鉴定出幽门螺杆菌（7.7%）。28 例有同时的组织学检查。总共有 4 例（3 例来自 2017 年，1 例来自 2018 年）在 H&E 切片中显示出与幽门螺杆菌形态相同的生物体，其中所有病例均对幽门螺杆菌具有免疫反应性。