[肽类激素的基因工程。I. 鸡生长激素cDNA的克隆及一级结构]
[Genetic engineering of peptide hormones. I. Cloning and primary structure of cDNA of chicken growth hormone].
作者信息
Zhvirblis G S, Gorbulev V G, Rubtsov P M, Karapetian R V, Zhuravlev I V
出版信息
Mol Biol (Mosk). 1987 Nov-Dec;21(6):1620-4.
The cDNA coding for the chicken growth hormone was cloned and sequenced. The 795 base pairs long cDNA insert contains a 5'-untranslated region (35 b.p.), a sequence coding for precursor of growth hormone (648 b.p.), a 3'-untranslated region (96 b.p.) and a poly(A)-tail (16 b.p.). Comparison of the cDNA sequence cloned by us with that published earlier revealed several differences including the additional unique HinfI site at the position corresponding to codons for Leu-87 and Thr-88.
编码鸡生长激素的cDNA被克隆并测序。这个795个碱基对长的cDNA插入片段包含一个5'-非翻译区（35个碱基对）、一个编码生长激素前体的序列（648个碱基对）、一个3'-非翻译区（96个碱基对）和一个聚腺苷酸尾（16个碱基对）。我们克隆的cDNA序列与之前发表的序列比较显示出几个差异，包括在对应于第87位亮氨酸和第88位苏氨酸密码子的位置有额外的独特HinfI位点。
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