Waksman Institute and Department of Genetics, Rutgers, the State University of New Jersey, Piscataway, New Jersey, USA.
Bioessays. 2022 Jan;44(1):e2100202. doi: 10.1002/bies.202100202. Epub 2021 Nov 25.
The chromosome passenger complex (CPC) localizes to chromosomes and microtubules, sometimes simultaneously. The CPC also has multiple domains for interacting with chromatin and microtubules. Interactions between the CPC and both the chromatin and microtubules is important for spindle assembly and error correction. Such dual chromatin-microtubule interactions may increase the concentration of the CPC necessary for efficient kinase activity while also making it responsive to specific conditions or structures in the cell. CPC-microtubule dependent functions are considered in the context of the first meiotic division. Acentrosomal spindle assembly is a process that depends on transfer of the CPC from the chromosomes to the microtubules. Furthermore, transfer to the microtubules is not only to position the CPC for a later role in cytokinesis; metaphase I error correction and subsequent bi-orientation of bivalents may depend on microtubule associated CPC interacting with the kinetochores.
染色体乘客复合物 (CPC) 定位于染色体和微管上,有时同时定位于两者上。CPC 还具有多个与染色质和微管相互作用的结构域。CPC 与染色质和微管之间的相互作用对于纺锤体组装和错误校正很重要。这种双重的染色质-微管相互作用可能会增加 CPC 发挥有效激酶活性所需的浓度,同时使其对细胞内的特定条件或结构做出响应。CPC-微管依赖性功能将在第一次减数分裂的背景下进行考虑。无中心体纺锤体的组装是一个依赖于 CPC 从染色体转移到微管上的过程。此外,向微管的转移不仅是为了将 CPC 定位到后期的胞质分裂中;中期 I 错误校正和随后的二价体的双定向可能依赖于与动粒相互作用的微管相关 CPC。