Milejski Wojciech, Sacha Jerzy, Feusette Piotr, Cisowski Marek, Muzyk Piotr, Tomasik Andrzej, Gierlotka Marek, Morawiec Beata, Kawecki Damian
2nd Department of Cardiology, Faculty of Medicine in Zabrze, Medical University of Silesia in Katowice, M. Skłodowskiej-Curie 10, 41-800 Zabrze, Poland.
Department of Cardiology, University Hospital in Opole, W. Witosa 26, 45-401 Opole, Poland.
J Cardiovasc Dev Dis. 2021 Nov 11;8(11):155. doi: 10.3390/jcdd8110155.
Percutaneous coronary intervention (PCI) of bifurcation lesions is a technical challenge associated with high risk of adverse events, especially in primary PCI. The aim of the study is to analyze long-term outcomes after PCI for coronary bifurcation in acute myocardial infarction (AMI). The outcome was defined as the rate of major adverse cardiac event related to target lesion failure (MACE-TLF) (death-TLF, nonfatal myocardial infarction-TLF and target lesion revascularization (TLR)) and the rate of stent thrombosis (ST). From 306 patients enrolled to the registry, 113 were diagnosed with AMI. In the long term, AMI was not a risk factor for MACE-TLF. The risk of MACE-TLF was dependent on the culprit lesion, especially in the right coronary artery (RCA) and side branch (SB) with a diameter >3 mm. When PCI was performed in the SB, the inflation pressure in SB remained the single risk factor of poor prognosis. The rate of cumulative ST driven by late ST in AMI was dependent on the inflation pressure in the main branch (MB). In conclusion, PCI of bifurcation culprit lesions should be performed carefully in case of RCA and large SB diameter and attention should be paid to high inflation pressure in the SB. On the contrary, the lower the inflation pressure in the MB, the higher the risk of ST.
冠状动脉分叉病变的经皮冠状动脉介入治疗(PCI)是一项技术挑战,伴有不良事件的高风险,尤其是在直接PCI中。本研究的目的是分析急性心肌梗死(AMI)患者冠状动脉分叉病变PCI后的长期预后。预后指标定义为与靶病变失败相关的主要不良心脏事件(MACE-TLF)发生率(死亡-TLF、非致命性心肌梗死-TLF和靶病变血运重建(TLR))以及支架血栓形成(ST)发生率。在纳入登记的306例患者中,113例被诊断为AMI。从长期来看,AMI并非MACE-TLF的危险因素。MACE-TLF的风险取决于罪犯病变,尤其是在直径>3 mm的右冠状动脉(RCA)和边支(SB)中。当在SB中进行PCI时,SB中的球囊扩张压力仍然是预后不良的唯一危险因素。AMI中由晚期ST驱动的累积ST发生率取决于主支(MB)中的球囊扩张压力。总之,对于RCA和较大SB直径的情况,应谨慎进行分叉罪犯病变的PCI,并应注意SB中的高球囊扩张压力。相反,MB中的球囊扩张压力越低,ST风险越高。