Department of Periodontology, School of Dentistry, Erciyes University, Kayseri, Turkey.
Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara University, Ankara, Turkey.
Clin Oral Investig. 2022 Feb;26(2):1121-1135. doi: 10.1007/s00784-021-04257-0. Epub 2021 Nov 25.
The aim of this study is to investigate the potential role of ANRIL polymorphisms in susceptibility to periodontitis.
The authors searched Pubmed, Web of Science, and Scopus up to April 2021 to identify all published studies without any language restriction on the association between ANRIL and periodontitis. A meta-analysis of all ANRIL variants replicated by three or more studies was performed by testing multiple genetic models of association. Pooled odds ratios and 95% confidence intervals (CI) were used to estimate associations. Tests for sensitivity and publication bias were performed.
Twenty-two variants in the ANRIL gene were examined for their potential association with the risk of periodontitis. However, only 4 (rs1333048, rs1333042, rs2891168, rs496892) are replicated at least three or more studies. The ANRIL rs1333048 was the most replicated polymorphisms with five articles, seven different populations comprising of 1331 cases, and 2624 controls. The pooled overall analysis showed that rs1333048, rs1333042, rs2891168, and rs496892 polymorphisms were associated with susceptibility to periodontitis in the whole population in allele contrast and dominant models. Moreover, similar to the overall analysis, rs1333048 polymorphism showed a significant association with grade C periodontitis (known as aggressive periodontitis in 1999 classification) in allele contrast (OR = 1.16) and dominant models (1.19). Interestingly, subgroup analysis also showed rs1333048 polymorphism might influence predisposition to a slowly progressive form of periodontitis (known as chronic periodontitis in 1999 classification).
Our findings suggest that the ANRIL rs1333048, rs1333042, rs2891168, and rs496892 polymorphisms might influence predisposition to periodontitis, particularly in Caucasians.
ANRIL gene may represent a potential risk marker for periodontitis.
本研究旨在探讨 ANRIL 多态性与牙周炎易感性的潜在关系。
作者检索了 Pubmed、Web of Science 和 Scopus 数据库，截至 2021 年 4 月，以确定所有关于 ANRIL 与牙周炎相关性的已发表研究，不限制语言。通过检测关联的多种遗传模型，对经 3 项或更多研究复制的所有 ANRIL 变体进行了荟萃分析。使用合并优势比和 95%置信区间（CI）来估计关联。进行了敏感性和发表偏倚检验。
共检测了 ANRIL 基因中的 22 个变体，以评估其与牙周炎风险的潜在关联。然而，只有 4 个（rs1333048、rs1333042、rs2891168、rs496892）被至少 3 项或更多研究复制。ANRIL rs1333048 是被复制最多的多态性，有 5 篇文章，涉及 7 个不同人群，包括 1331 例病例和 2624 例对照。总体合并分析显示，rs1333048、rs1333042、rs2891168 和 rs496892 多态性在总体人群中与等位基因对比和显性模型的牙周炎易感性相关。此外，与总体分析相似，rs1333048 多态性在等位基因对比（OR=1.16）和显性模型（1.19）中与 C 级牙周炎（1999 年分类中称为侵袭性牙周炎）显著相关。有趣的是，亚组分析还表明，rs1333048 多态性可能影响慢性牙周炎（1999 年分类中称为慢性牙周炎）的缓慢进展形式的易感性。
我们的研究结果表明，ANRIL rs1333048、rs1333042、rs2891168 和 rs496892 多态性可能影响牙周炎的易感性，尤其是在白种人中。
ANRIL 基因可能是牙周炎的一个潜在风险标志物。
