Department of Ophthalmology, Pamukkale University, Denizli, Turkey.
Department of Ophthalmology, Denizli State Hospital, Denizli, Turkey.
Arq Bras Oftalmol. 2021 May-Jun;84(3):220-224. doi: 10.5935/0004-2749.20210030.
To evaluate the corneal and anterior chamber morphology in phakic eyes with noninfectious intraocular inflammation.
This study included 59 eyes with active uveitis, 62 with inactive uveitis, and 95 healthy eyes. Corneal endothelial cell density, hexagonal cell ratio, coefficient of variation (CV), corneal thickness and volume, maximum keratometry, and anterior chamber volume and depth (ACD) measurements were performed using a specular microscope and Pentacam HR.
The mean duration of uveitis was 24.6 ± 40.5 (0-180) months. The mean number of uveitis attacks was 2.8 ± 3.0 (1-20). Coefficient of variation was significantly higher in the active uveitis group compared with inactive uveitis group (p=0.017, Post Hoc Tukey). Anterior segment parameters other than coefficient of variation were not significantly different between active/inactive uveitis and control groups (p>0.05). Multiple linear regression analysis showed that coefficient of variation was greater in active uveitis compared with inactive uveitis after adjusting for the duration of uveitis, type of uveitis, having a rheumatologic disease, and having immunosuppressive treatment (p=0.003). The duration of uveitis and number of attacks were not significantly correlated with ocular parameters (p>0.05, Spearman's correlation). The difference in parameters was not significant based on uveitis type (p>0.05).
Coefficient of variation was higher in eyes with active uveitis than that in eyes with inactive uveitis, whereas corneal endothelial cell density and anterior chamber morphology did not significantly differ between active/inactive uveitis and control groups.
评估非感染性眼内炎症患者的有晶状体眼的角膜和前房形态。
本研究纳入了 59 只活动期葡萄膜炎眼、62 只非活动期葡萄膜炎眼和 95 只健康眼。使用角膜内皮显微镜和 Pentacam HR 测量角膜内皮细胞密度、六边形细胞比例、变异系数（CV）、角膜厚度和体积、最大角膜曲率以及前房容积和深度（ACD）。
葡萄膜炎的平均病程为 24.6±40.5（0-180）个月。葡萄膜炎的平均发作次数为 2.8±3.0（1-20）次。与非活动期葡萄膜炎组相比，活动期葡萄膜炎组的 CV 显著更高（p=0.017，Post Hoc Tukey）。除 CV 外，前节参数在活动期/非活动期葡萄膜炎眼和对照组之间无显著差异（p>0.05）。多元线性回归分析显示，在校正葡萄膜炎病程、葡萄膜炎类型、是否患有风湿性疾病和是否接受免疫抑制治疗后，活动期葡萄膜炎的 CV 显著大于非活动期葡萄膜炎（p=0.003）。葡萄膜炎病程和发作次数与眼部参数无显著相关性（p>0.05，Spearman 相关）。基于葡萄膜炎类型，参数差异无统计学意义（p>0.05）。
与非活动期葡萄膜炎眼相比，活动期葡萄膜炎眼的 CV 更高，而角膜内皮细胞密度和前房形态在活动期/非活动期葡萄膜炎眼和对照组之间无显著差异。
