Yılmaz Çebi Aslıhan, Kılıçarslan Oğuzhan, Kasapçopur Özgür, Uçar Didar
Department of Ophthalmology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Kocamustafapasa St, 34098, Fatih, Istanbul, Turkey.
Department of Ophthalmology, Ayancık State Hospital, Sinop, Turkey.
Int Ophthalmol. 2023 Feb;43(2):635-641. doi: 10.1007/s10792-022-02467-3. Epub 2022 Aug 25.
To assess corneal topography and specular microscopy values in juvenile idiopathic arthritis-related uveitis (JIA-U).
This case-control study included 30 eyes from JIA-U patients, 20 eyes from JIA patients, and 50 eyes from age- and gender-matched healthy subjects. Patients with a history of ocular diseases or intraocular surgery were excluded. Corneal topography maps (Pentacam HR) and specular microscopy images (CellChek SL) were obtained. The measurements of the groups were compared.
Keratometric astigmatism was higher in the JIA-U group than in the control group (p = 0.040). Patients with astigmatism greater than 1.50D were more common in the JIA-U group than in the control group (p = 0.026). The JIA-U group had higher anterior and posterior elevation values than the control group (p = 0.006, p = 0.025). The density of endothelial cells, coefficient of variation, and hexagonality did not change across groups (p = 0.465, p = 0.096, p = 0.869). The total number of exacerbations and the duration of anterior chamber inflammation were both positively correlated with posterior elevation (r = 0.600, p 0.001; r = 0.583, p 0.001). The age of diagnosis was found to be negatively correlated with anterior elevation (r = -0.412, p = 0.021).
Corneal astigmatism, as well as anterior and posterior elevation values, were all higher in JIA-U patients. Endothelial cell density and morphology, on the other hand, did not differ significantly between groups. Chronic inflammation's impact on stromal remodelling could explain these corneal alterations. The positive correlation between posterior elevation and the number of flares and duration of inflammation represents the importance of early diagnosis and effective treatment.
评估青少年特发性关节炎相关葡萄膜炎（JIA-U）患者的角膜地形图和角膜内皮显微镜检查值。
本病例对照研究纳入了30只JIA-U患者的眼睛、20只JIA患者的眼睛以及50只年龄和性别匹配的健康受试者的眼睛。排除有眼部疾病或眼内手术史的患者。获取角膜地形图（Pentacam HR）和角膜内皮显微镜图像（CellChek SL）。比较各组的测量结果。
JIA-U组的角膜散光度数高于对照组（p = 0.040）。散光度数大于1.50D的患者在JIA-U组中比对照组更常见（p = 0.026）。JIA-U组的前、后表面高度值高于对照组（p = 0.006，p = 0.025）。各组间内皮细胞密度、变异系数和六角形细胞比例无变化（p = 0.465，p = 0.096，p = 0.869）。炎症发作总数和前房炎症持续时间均与后表面高度呈正相关（r = 0.600，p < 0.001；r = 0.583，p < 0.001）。诊断年龄与前表面高度呈负相关（r = -0.412，p = 0.021）。
JIA-U患者的角膜散光以及前、后表面高度值均较高。另一方面，各组间内皮细胞密度和形态无显著差异。慢性炎症对基质重塑的影响可能解释了这些角膜改变。后表面高度与炎症发作次数和炎症持续时间的正相关表明了早期诊断和有效治疗的重要性。
