童年期慢性应激与药物初治、首发青少年 MDD 患者动态功能连接的相关性。
Associations between childhood chronic stress and dynamic functional connectivity in drug-naïve, first-episode adolescent MDD.
机构信息
Department of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, Sichuan 610041, China.
Department of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Chengdu, Sichuan 610041, China; Frontier Science Center for Disease-related Molecular Networks, Chengdu, Sichuan 610041, China; Sichuan Clinical Medical Research Center for Mental Disorders, Chengdu, Sichuan 610041, China.
出版信息
J Affect Disord. 2022 Feb 15;299:85-92. doi: 10.1016/j.jad.2021.11.050. Epub 2021 Nov 22.
BACKGROUND
We explored the associations between chronic stress and dynamic working patterns of the whole brain using resting state MRI data in drug-naïve, first-episode adolescents with major depressive disorder (MDD).
METHODS
We compared dynamic functional connectivity (dyn-FC) and screen out networks with difference in whole brain between 45 healthy controls (HC) and 60 adolescent MDD patients using dynamic independent components analysis. In each of these networks with difference between groups, hub brain regions were selected as functionally connected to more than 30 brain regions at the same time. Then we extracted the dyn-FC coefficients of each hub brain region with other brain regions in each component at different time points and calculated the average value of the entire scan time. Finally, we explored correlations between these average values of the entire scan time and scores on the Childhood Chronic Stress Questionnaire (CCSQ).
RESULTS
We found three networks as well as some hub brain regions with different dyn-FC patterns between adolescent MDD and HC. Scores on the CCSQ were found to correlate with dynamic FC between hub brain areas and certain other brain areas in MDD patients.
LIMITATIONS
our cross-sectional study design does not allow us to speculate about causality between chronic stress and depression. Prospective cohort studies should explore in detail how the changes in dynamic FC appear and evolve during MDD.
CONCLUSIONS
Chronic stress is related with the brain dynamic working patterns in adolescent MDD.
背景
我们利用静息态磁共振成像数据，研究了未接受药物治疗的首发青少年抑郁症（MDD）患者慢性应激与全脑动态工作模式之间的关系。
方法
我们采用动态独立成分分析，比较了 45 名健康对照者（HC）和 60 名青少年 MDD 患者之间整个大脑动态功能连接（dyn-FC）和差异筛出网络。在这些具有组间差异的网络中，选择了每个网络的中枢脑区，作为同时与超过 30 个脑区功能连接的脑区。然后，我们从每个组件中每个中枢脑区与其他脑区在不同时间点的 dyn-FC 系数中提取出来，并计算整个扫描时间的平均值。最后，我们探讨了这些整个扫描时间的平均值与童年期慢性应激问卷（CCSQ）评分之间的相关性。
结果
我们发现了三个网络以及一些中枢脑区在青少年 MDD 和 HC 之间存在不同的 dyn-FC 模式。CCSQ 评分与 MDD 患者中枢脑区与其他某些脑区之间的动态 FC 相关。
局限性
我们的横断面研究设计不允许我们推测慢性应激与抑郁之间的因果关系。前瞻性队列研究应详细探讨动态 FC 的变化如何在 MDD 期间出现和演变。
结论
慢性应激与青少年 MDD 大脑的动态工作模式有关。
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