Luo Qianyi, Yu Huiwen, Chen Juran, Lin Xinyi, Wu Zhiyao, Yao Jiazheng, Li Yuhong, Wu Huawang, Peng Hongjun
Department of Clinical Psychology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Radiology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
Front Neurosci. 2022 May 9;16:852799. doi: 10.3389/fnins.2022.852799. eCollection 2022.
Childhood trauma is a non-specific risk factor for major depressive disorder (MDD). resting-state functional magnetic resonance imaging (R-fMRI) studies have demonstrated changes in regional brain activity in patients with MDD who experienced childhood trauma. However, previous studies have mainly focused on static characteristics of regional brain activity. This study aimed to determine the specific brain regions associated with MDD with childhood trauma by performing temporal dynamic analysis of R-fMRI data in three groups of patients: patients with childhood trauma-associated MDD ( = 48), patients without childhood trauma-associated MDD ( = 30), and healthy controls ( = 103). Dynamics and concordance of R-fMRI indices were calculated and analyzed. In patients with childhood trauma-associated MDD, a lower dynamic amplitude of low-frequency fluctuations was found in the left lingual gyrus, whereas a lower dynamic degree of centrality was observed in the right lingual gyrus and right calcarine cortex. Patients with childhood trauma-associated MDD showed a lower voxel-wise concordance in the left middle temporal and bilateral calcarine cortices. Moreover, group differences (depressed or not) significantly moderated the relationship between voxel-wise concordance in the right calcarine cortex and childhood trauma history. Overall, patients with childhood trauma-associated MDD demonstrated aberrant variability and concordance in intrinsic brain activity. These aberrances may be an underlying neurobiological mechanism that explains MDD from the perspective of temporal dynamics.
童年创伤是重度抑郁症（MDD）的一个非特异性风险因素。静息态功能磁共振成像（R-fMRI）研究表明，经历过童年创伤的MDD患者大脑区域活动存在变化。然而，以往的研究主要集中在大脑区域活动的静态特征上。本研究旨在通过对三组患者的R-fMRI数据进行时间动态分析，确定与童年创伤相关的MDD的特定脑区：童年创伤相关MDD患者（n = 48）、无童年创伤相关MDD患者（n = 30）和健康对照者（n = 103）。计算并分析了R-fMRI指标的动态性和一致性。在童年创伤相关MDD患者中，左侧舌回低频波动的动态幅度较低，而右侧舌回和右侧距状皮质的动态中心度较低。童年创伤相关MDD患者在左侧颞中回和双侧距状皮质的体素一致性较低。此外，组间差异（是否抑郁）显著调节了右侧距状皮质体素一致性与童年创伤史之间的关系。总体而言，童年创伤相关MDD患者在内在脑活动中表现出异常的变异性和一致性。这些异常可能是从时间动态角度解释MDD的潜在神经生物学机制。
