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腰椎退行性狭窄症减压与短节段或长节段内固定融合术后的临床结果。一项前瞻性病例对照分析。

Clinical outcome following decompression and short or long instrumented fusion in lumbar degenerative spinal stenosis. A prospective case-control analysis.

机构信息

Department of Neurosurgery, Papageorgiou General Hospital, Thessaloniki, Greece.

Department of Neurosurgery, Ioannina University Hospital, University of Ioannina, Ioannina, Greece.

出版信息

Clin Neurol Neurosurg. 2021 Dec;211:107038. doi: 10.1016/j.clineuro.2021.107038. Epub 2021 Nov 21.

DOI:10.1016/j.clineuro.2021.107038
PMID:34823153
Abstract

OBJECTIVES

There is limited data on the direct clinical comparison between short and long fusion following surgery for lumbar spinal stenosis. The hypothesis that regardless their baseline characteristics and morbidity, clinical outcome is similar in patients with lumbar stenosis treated with decompression plus posterior instrumented fusion in one or two versus three to five levels was tested.

METHODS

Subjects were divided into Group A and Group B corresponding to stenotic pathology and instrumented fusion in one or two levels and three to five levels, respectively. Primary outcome measures at one year were the change in SF-36 physical component (PCS) and Oswestry Disability Index (ODI). Secondary outcome measures included the EuroQol-5D (EQ-5D), the Visual Analog Scale (VAS), the mental component (MCS) of SF-36 scale and the Zung Self-Rating Depression Scale.

RESULTS

Seventy seven (77) patients were included (Group A, n = 42; Group B, n = 35). Patients in Group B were older, surgery lasted longer and intraoperative blood loss was greater than patients in Group A (p < 0.05). A significant clinical improvement was noted in both Groups on all scales (p < 0.01). Clinical outcome at one year was equally favorable in both Groups (p > 0.05). The evaluation of depression for Group A showed a significant improvement at one year (p = 0.02) compared to the preoperative status.

CONCLUSIONS

Older individuals are more likely to have multilevel stenosis and more co-morbidities and they were associated with longer instrumentation. However, complications are similar and clinical outcome is equally favorable compared to short instrumented fusion for fewer levels of disease.

摘要

目的

关于腰椎管狭窄症手术后短节段与长节段融合的直接临床比较,数据有限。本研究假设无论基线特征和发病率如何,在减压加后路器械融合治疗腰椎管狭窄症患者中,在一个或两个节段与三个至五个节段相比,临床结果是相似的。

方法

根据狭窄病变和一个或两个节段与三个至五个节段的器械融合,将受试者分为 A 组和 B 组。主要的一年期预后指标是 SF-36 生理成分(PCS)和 Oswestry 功能障碍指数(ODI)的变化。次要预后指标包括欧洲五维健康量表(EQ-5D)、视觉模拟量表(VAS)、SF-36 量表的心理成分(MCS)和 Zung 自评抑郁量表。

结果

77 例患者入选(A 组,n=42;B 组,n=35)。B 组患者年龄较大,手术时间较长,术中出血量也大于 A 组(p<0.05)。两组患者在所有量表上均有显著的临床改善(p<0.01)。两组患者一年的临床结果同样良好(p>0.05)。与术前相比,A 组患者的抑郁评估在一年时显著改善(p=0.02)。

结论

年龄较大的患者更有可能患有多节段狭窄症和更多的合并症,并且与更长的器械相关。然而,并发症相似,与较少节段疾病的短节段器械融合相比,临床结果同样良好。

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