Rare Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, South Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology, Daejeon, South Korea.
Rare Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, South Korea.
J Hazard Mater. 2022 Mar 15;426:127815. doi: 10.1016/j.jhazmat.2021.127815. Epub 2021 Nov 18.
As global plastic production continues to grow, microplastics released from a massive quantity of plastic wastes have become a critical environmental concern. These microplastic particles are found in a wide range of living organisms in a diverse array of ecosystems. In this study, we investigated the biological effects of polystyrene nanoplastic (PSNP) on development of the central nervous system using cultured neural stem cells (NSCs) and mice exposed to PSNP during developmental stages. Our study demonstrates that maternal administration of PSNP during gestation and lactating periods altered the functioning of NSCs, neural cell compositions, and brain histology in progeny. Similarly, PSNP-induced molecular and functional defects were also observed in cultured NSCs in vitro. Finally, we show that the abnormal brain development caused by exposure to high concentrations of PSNP results in neurophysiological and cognitive deficits in a gender-specific manner. Our data demonstrate the possibility that exposure to high amounts of PSNP may increase the risk of neurodevelopmental defects.
随着全球塑料产量的持续增长，大量塑料废弃物释放的微塑料已成为一个严峻的环境问题。这些微塑料颗粒在各种生态系统的多种生物中都有发现。在本研究中，我们使用培养的神经干细胞（NSCs）和在发育阶段暴露于 PSNP 的小鼠，研究了聚苯乙烯纳米塑料（PSNP）对中枢神经系统发育的生物学影响。我们的研究表明，妊娠和哺乳期母体给予 PSNP 会改变后代 NSCs 的功能、神经细胞组成和脑组织学。同样，在体外培养的 NSCs 中也观察到 PSNP 诱导的分子和功能缺陷。最后，我们表明，暴露于高浓度 PSNP 导致的异常大脑发育以性别特异性的方式导致神经生理和认知缺陷。我们的数据表明，接触大量 PSNP 可能会增加神经发育缺陷的风险。
