Department of Molecular Biology and Institute of Genetics and Genomics in Geneva, Section of Biology, Faculty of Sciences, University of Geneva, 1211 Geneva, Switzerland.
Department of Molecular Biology and Institute of Genetics and Genomics in Geneva, Section of Biology, Faculty of Sciences, University of Geneva, 1211 Geneva, Switzerland.
Semin Cell Dev Biol. 2022 Jul;127:133-141. doi: 10.1016/j.semcdb.2021.11.008. Epub 2021 Nov 22.
Epigenetic inheritance refers to the transmission of phenotypes across generations without affecting the genomic DNA sequence. Even though it has been documented in many species in fungi, animals and plants, the mechanisms underlying epigenetic inheritance are not fully uncovered. Epialleles, the heritable units of epigenetic information, can take the form of several biomolecules, including histones and their post-translational modifications (PTMs). Here, we review the recent advances in the understanding of the transmission of histone variants and histone PTM patterns across generations in C. elegans. We provide a general overview of the intergenerational and transgenerational inheritance of histone PTMs and their modifiers and discuss the interplay among different histone PTMs. We also evaluate soma-germ line communication and its impact on the inheritance of epigenetic traits.
表观遗传遗传是指表型在不影响基因组 DNA 序列的情况下跨代传递。尽管在真菌、动物和植物的许多物种中都有记录，但表观遗传遗传的机制尚未完全揭示。表观等位基因是表观遗传信息的可遗传单位，可以采用多种生物分子的形式，包括组蛋白及其翻译后修饰 (PTM)。在这里，我们回顾了近年来在理解线虫中组蛋白变体和组蛋白 PTM 模式跨代传递方面的进展。我们提供了组蛋白 PTM 及其修饰物的跨代和世代间遗传的概述，并讨论了不同组蛋白 PTM 之间的相互作用。我们还评估了体-生殖系通讯及其对表观遗传特征遗传的影响。
