Division of Cell Signalling and Immunology, University of Dundee, UK.
Division of Cell Signalling and Immunology, University of Dundee, UK.
Semin Immunol. 2021 Mar;53:101532. doi: 10.1016/j.smim.2021.101532. Epub 2021 Nov 22.
IL-33 is an alarmin cytokine which has been implicated in allergy, fibrosis, inflammation, tumorigenesis, metabolism, and homeostasis. However, amongst its strongest roles are in helminth infections, where IL-33 usually (but not always) is central to induction of an effective anti-parasitic immune response. In this review, we will summarise the literature around this fascinating cytokine, its activity on immune and non-immune cells, the unique (and sometimes counterintuitive) responses it induces, and how it can coordinate the immune response during infections by parasitic helminths. Finally, we will summarise some of the ways that parasites have developed to modulate the IL-33 pathway for their own benefit.
IL-33 是一种警报素细胞因子，与过敏、纤维化、炎症、肿瘤发生、代谢和内稳态有关。然而，它在寄生虫感染中的作用最为突出，IL-33 通常（但不总是）是诱导有效抗寄生虫免疫反应的关键。在这篇综述中，我们将总结围绕这种迷人的细胞因子的文献，它对免疫细胞和非免疫细胞的作用，它诱导的独特（有时是违反直觉的）反应，以及它如何在寄生虫引起的感染过程中协调免疫反应。最后，我们将总结一些寄生虫为了自身利益而调节 IL-33 途径的方法。
