Bhavyaa R, Vignesh K C, Muthu M S, Haridoss Selvakumar, Abirami S
Department of Pediatric and Preventive Dentistry, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Centre for Early Childhood Caries Research (CECCRe), Department of Pediatric and Preventive Dentistry, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India; Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates.
Int J Clin Pediatr Dent. 2021 Jul-Aug;14(4):580-585. doi: 10.5005/jp-journals-10005-1973.
Glanzmann thrombasthenia is a rare bleeding disorder due to defects in the glycoprotein Ilb/IIIa complex present on the platelet membrane. The most common mode of treatment for this disorder is platelet transfusion. However, scientific evidence does state that repeated transfusions could lead to auto immunization making transfusions ineffective.
To describe the use of a novel technique of soft splint with tranexamic acid paste to stop oral bleeding in a patient with Glanzmann thrombasthenia (GT).
A 7-year-old female patient with a known history of GT was referred to the pediatric department. The chief complaint of the patient revealed a history of spontaneous bleeding from the oral cavity. The patient required multiple teeth extractions due to severely carious teeth. History revealed that the patient was admitted to the hospital (casualty) three times within 1 month due to a similar complaint leading to hypovolemic shock. Several transfusion procedures were done to stop the spontaneous bleeding. To stop the intraoral bleeding without transfusions, a novel method of using a soft splint with tranexamic acid paste (500 mg tablet crushed and mixed with saline) in the area of spontaneous bleeding was employed with a successful follow-up of 7 months.
Soft splint with the tranexamic acid paste can serve as an effective method of treatment for patients with spontaneous oral bleeding due to medical conditions like GT.
This case report highlights the need for awareness among all the healthcare providers about the importance of regular dental visits. The healthcare providers also need to emphasize the same to all patients with medical conditions to avoid such life-threatening situations.
Bhavyaa R, Vignesh KC, Muthu MS, Glanzmann Thrombasthenia: Use of the Soft Splint with Tranexamic Acid Paste to Reduce Spontaneous Oral Bleeding. Int J Clin Pediatr Dent 2021;14(4):580-585.
血小板无力症是一种罕见的出血性疾病，由于血小板膜上存在的糖蛋白IIb/IIIa复合物缺陷所致。这种疾病最常见的治疗方式是血小板输注。然而，科学证据确实表明，反复输血可能导致自身免疫，使输血无效。
描述使用一种新型技术，即含氨甲环酸糊剂的软夹板，以止住血小板无力症（GT）患者的口腔出血。
一名有GT病史的7岁女性患者被转诊至儿科。患者的主要诉求显示有口腔自发出血史。由于严重龋齿，患者需要拔除多颗牙齿。病史显示，患者因类似症状在1个月内3次入住医院（急诊），导致低血容量性休克。进行了多次输血程序以止住自发出血。为了不输注血液而止住口腔内出血，采用了一种在自发出血区域使用含氨甲环酸糊剂（将500毫克片剂碾碎并与盐水混合）的软夹板的新方法，并成功随访了7个月。
含氨甲环酸糊剂的软夹板可作为治疗因GT等病症导致口腔自发出血患者的有效方法。
本病例报告强调了所有医疗保健提供者都需要意识到定期看牙的重要性。医疗保健提供者还需要向所有患有疾病的患者强调这一点，以避免此类危及生命的情况。
Bhavyaa R, Vignesh KC, Muthu MS, 血小板无力症：使用含氨甲环酸糊剂的软夹板减少口腔自发出血。《国际临床儿科牙科学杂志》2021年；14(4):580 - 585。
