Soibi-Harry Adaiah Priscilla, Amaeshi Lemchukwu Chukwunonye, Garba Sunusi Rimi, Anorlu Rose Ihuoma
Oncology & Pathological Studies Unit, Department of Obstetrics & Gynaecology, Lagos University Teaching Hospital, Lagos 101233, Nigeria.
Clinical Haematology and Oncology Unit, Department of Medicine, Lagos University Teaching Hospital, Lagos 101233, Nigeria.
Ecancermedicalscience. 2021 Sep 14;15:1288. doi: 10.3332/ecancer.2021.1288. eCollection 2021.
Ovarian cancer (OC) is the second most common genital cancer worldwide, and the most lethal of all genital cancers. The role of inflammation and markers of systemic inflammation such as neutrophils, lymphocytes and monocytes in cancer biology have been investigated and reported in many studies. Cancer antigen 125 (CA-125) is currently in use as an adjunct to diagnosis, prognostication and monitoring of epithelial OC (EOC). This test is not readily available in many centres in sub-Saharan Africa, creating a need to identify alternative markers that are available and affordable. This study aimed to determine the relationship between pre-operative serum lymphocyte to monocyte ratio (LMR) and CA-125 in EOC. This was a retrospective cross-sectional study among 70 women, diagnosed with EOC in Lagos University Teaching Hospital from January 2013 to December 2019. Data were extracted from the case notes of the patients. LMR was calculated as the absolute lymphocyte count divided by the absolute monocyte count and analysed using Statistical Package for Social Sciences (SPSS) version 25.0. The correlation between LMR and CA-125 was determined using Pearson's correlation coefficient. The mean age of the patients was 48.57 ± 13.97 years. Serous adenocarcinoma was the most common subtype of EOC making up 94.3% of the cases. The median serum CA-125 was 393.5 (215.00-765.67) U/mL. The median LMR was 6.77 (1.28-43.0). There was a statistically significant negative correlation between CA-125 and LMR, = -0.28, = 0.02. LMR was negatively associated with CA-125 in women with EOC. LMR may be considered as a simple, affordable alternative marker to CA-125 in the management of EOC.
卵巢癌（OC）是全球第二常见的妇科癌症，也是所有妇科癌症中致死率最高的。炎症以及中性粒细胞、淋巴细胞和单核细胞等全身炎症标志物在癌症生物学中的作用已在许多研究中得到调查和报道。癌抗原125（CA-125）目前被用作上皮性卵巢癌（EOC）诊断、预后评估和监测的辅助手段。在撒哈拉以南非洲的许多中心，这项检测并不容易获得，因此需要确定可用且负担得起的替代标志物。本研究旨在确定EOC患者术前血清淋巴细胞与单核细胞比值（LMR）与CA-125之间的关系。这是一项回顾性横断面研究，研究对象为2013年1月至2019年12月在拉各斯大学教学医院被诊断为EOC的70名女性。数据从患者的病历中提取。LMR的计算方法是绝对淋巴细胞计数除以绝对单核细胞计数，并使用社会科学统计软件包（SPSS）25.0版进行分析。LMR与CA-125之间的相关性使用Pearson相关系数确定。患者的平均年龄为48.57±13.97岁。浆液性腺癌是EOC最常见的亚型，占病例的94.3%。血清CA-125的中位数为393.5（215.00-765.67）U/mL。LMR的中位数为6.77（1.28-43.0）。CA-125与LMR之间存在统计学上显著的负相关，r = -0.28，P = 0.02。在EOC女性中，LMR与CA-125呈负相关。在EOC的管理中，LMR可被视为一种简单、经济的CA-125替代标志物。
