Popa Liliana Gabriela, Giurcaneanu Calin, Nitipir Cornelia, Popa Ana Maria, Stoica Cristiana, Beiu Cristina, Tebeica Tiberiu, Negoita Silvius, Mihai Mara Madalina
Department of Dermatology, 'Elias' Emergency University Hospital, 011461 Bucharest, Romania.
Department of Oncologic Dermatology, 'Elias' Emergency University Hospital, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Exp Ther Med. 2022 Jan;23(1):31. doi: 10.3892/etm.2021.10953. Epub 2021 Nov 8.
Multiple primary cancers may occur in the same patient, with a prevalence that follows an ascendant trend. Their development is dictated by a complex interplay between a variety of factors, both patient-dependent and external. The case of a 38-year-old female patient diagnosed and treated for pancreatic cancer (PC) is presented in whom the digital dermoscopic monitoring of melanocytic nevi revealed a marked change of two nevi that acquired rapidly highly atypical features. They were surgically excised and the histopathological examination revealed two completely excised dysplastic compound nevi. Clinicians should be aware of the strong association between dysplastic nevus syndrome and PC, a malignancy associated with an extremely poor prognosis. Familial atypical multiple mole melanoma syndrome (FAMMM) predisposes to the development of melanoma, pancreatic cancer and other neoplasms. The common genetic background of PC and hereditary melanoma is discussed and the importance of regular skin checkup and screening for PC in these patients is underlined.
同一患者可能发生多种原发性癌症，其患病率呈上升趋势。它们的发生由多种因素（包括患者自身因素和外部因素）之间复杂的相互作用所决定。本文介绍了一名38岁女性胰腺癌（PC）患者的病例，对其黑素细胞痣进行数字皮肤镜监测时发现两个痣有明显变化，迅速出现高度非典型特征。这两个痣被手术切除，组织病理学检查显示为两个完全切除的发育异常复合痣。临床医生应意识到发育异常痣综合征与胰腺癌之间的密切关联，胰腺癌是一种预后极差的恶性肿瘤。家族性非典型多发性痣黑色素瘤综合征（FAMMM）易患黑色素瘤、胰腺癌和其他肿瘤。本文讨论了胰腺癌和遗传性黑色素瘤的共同遗传背景，并强调了对这些患者进行定期皮肤检查和胰腺癌筛查的重要性。
