College of Medical and Health Technologies, Ahlulbyt University, Karbala, Iraq.
Arch Razi Inst. 2021 Sep 1;76(3):639-647. doi: 10.22092/ari.2021.355463.1688. eCollection 2021 Summer.
Obesity triggers the development of adipokines such as leptin, resistin, and visfatin, which have been associated with the development of diabetic nephropathy and other vascular disorders. The main purpose of the current investigation was to identify the physiological impact of visfatin on immunological response and its inflammatory effects on nephropathy. Fifty Iraqi patients with chronic kidney disease (CKD) at various stages, as described by the National Kidney Foundation (NKF) and ranging in age from 48.367.56 to 53.68 8.46 years on average were considered. Prior to the start of the investigation, informed consent was obtained from all participants, and the ethics committee approved the study. Patients were classified into two groups: Group (A) comprised patients with a GFR higher than 60 mL/minute, and Group (B) comprised patients with a GFR of less than 60 mL/min. There was no considerable variance between the groups as regards visfatin, but a highly significant correlation between serum visfatin and CRP was observed. The results of the current investigation indicated that serum visfatin levels are significantly correlated with CRP in CKD patients; it is also correlated with deterioration of kidney function. Moreover, higher visfatin levels were accompanied by increased serum triglyceride and cholesterol levels. These findings would suggest that visfatin may perform an essential function in uremia-related inflammation and may serve as a potential target for treatment and prevention of renal associated complications. Future studies may delineate whether visfatin is a marker of disease activity and severity as well as a predictor of outcome in CKD.
肥胖会引发脂联素等脂肪因子的产生，这些因子与糖尿病肾病和其他血管疾病的发生有关。本研究的主要目的是确定内脂素对免疫反应的生理影响及其对肾病的炎症作用。考虑了 50 名患有慢性肾脏病（CKD）的伊拉克患者，这些患者的病情处于不同阶段，根据美国国家肾脏病基金会（NKF）的描述，年龄在 48.367.56 到 53.68 8.46 岁之间，平均年龄为 50.875 岁。在开始研究之前，所有参与者都获得了知情同意，伦理委员会批准了这项研究。患者被分为两组：A 组患者的肾小球滤过率（GFR）高于 60mL/min，B 组患者的 GFR 低于 60mL/min。两组在脂联素方面没有明显差异，但血清脂联素与 CRP 之间存在高度显著的相关性。本研究结果表明，CKD 患者血清脂联素水平与 CRP 显著相关，与肾功能恶化相关。此外，脂联素水平升高与血清甘油三酯和胆固醇水平升高有关。这些发现表明，脂联素可能在尿毒症相关炎症中发挥重要作用，并可能成为治疗和预防肾脏相关并发症的潜在靶点。未来的研究可能会阐明脂联素是否是疾病活动和严重程度的标志物，以及 CKD 患者预后的预测因子。
