De Rosa G, Della Casa S, Corsello S M, Cecchini L, Callà C
Institute of Endocrinology, Catholic University School of Medicine, Rome, Italy.
Clin Endocrinol (Oxf). 1987 Nov;27(5):535-43. doi: 10.1111/j.1365-2265.1987.tb01183.x.
A young man is reported with an autoimmune polyglandular syndrome (APS) characterized by Addison's disease, primary hypothyroidism, primary hypogonadism, vitiligo, associated with primary empty sella and partial impairment of pituitary hormone secretion. Two years later the patient showed a null cell type acute lymphocytic leukaemia, immediately after surgery for an inguinal hernia. Pathogenetic mechanisms are postulated on the basis of HLA studies and lymphocytic typing.
据报道，一名年轻男性患有自身免疫性多腺体综合征（APS），其特征为艾迪生病、原发性甲状腺功能减退、原发性性腺功能减退、白癜风，伴有原发性空蝶鞍和垂体激素分泌部分受损。两年后，该患者在腹股沟疝手术后立即出现了无细胞型急性淋巴细胞白血病。基于HLA研究和淋巴细胞分型推测了发病机制。
