Akçurin S, Ocal G, Berberoğlu M, Memioğlu N
Pediatric Endocrinology and Metabolism Department, Ankara Faculty of Medicine, Turkey.
Acta Paediatr Jpn. 1995 Jun;37(3):347-51.
Empty sella syndrome (ESS) is a multicausal entity. The incidence of primary empty sella syndrome (PESS) in children with neuroendocrine dysfunction is not known. In the pediatric age group, frequency seems to have been underestimated. A total of 117 cases of neuroendocrine disorders, including complete growth hormone deficiency, primary hypothyroidism with pituitary resistance to thyroid hormone, obesity, central precocious puberty, hypothalamic hypogonadism and central diabetes insipidus, have been studied with computed tomography and/or magnetic resonance imaging of sellar region for etiologic evaluation. Twenty-one patients were found to have PESS. We noted a high incidence of PESS in children with neuroendocrine dysfunction (17.9%). Children with neuroendocrine dysfunction should be investigated with respect to PESS, and children with PESS recognized coincidentally should be studied with the particular consideration of subclinical neuroendocrine dysfunction.
空蝶鞍综合征（ESS）是一种多病因疾病。神经内分泌功能障碍儿童中原发性空蝶鞍综合征（PESS）的发病率尚不清楚。在儿童年龄组中，其发生率似乎被低估了。对117例神经内分泌疾病患者进行了蝶鞍区计算机断层扫描和/或磁共振成像检查以进行病因评估，这些疾病包括完全性生长激素缺乏症、原发性甲状腺功能减退伴垂体对甲状腺激素抵抗、肥胖症、中枢性性早熟、下丘脑性腺功能减退和中枢性尿崩症。发现21例患者患有PESS。我们注意到神经内分泌功能障碍儿童中PESS的发生率很高（17.9%）。对于神经内分泌功能障碍儿童应就PESS进行检查，而偶然发现患有PESS的儿童应特别考虑亚临床神经内分泌功能障碍进行研究。
