Thakur Pratibha, Shrivastava Renu, Shrivastava Vinoy K
Endocrinology Unit, Bioscience Department, Barkatullah University, Bhopal, Madhya Pradesh, 462026, India.
Zoology Department, Sri Sathya Sai, College for Women, Bhopal, Madhya Pradesh, 262024, India.
Metabol Open. 2021 Nov 2;12:100146. doi: 10.1016/j.metop.2021.100146. eCollection 2021 Dec.
Growing evidence suggests that oxytocin (OT) plays an important factor for the control of food intake, body weight, and energy metabolism in human and non-human animals. It has reported previously, the downregulation in oxytocin receptors (OTRs) expression is linked with the development of obesity, but exogenous OT reverse body weight and food intake in obese animal model. It is important to know that, whether intraperitoneal administration crosses blood brain barrier. Therefore, in the present experiment, we study the impact of intraperitoneal administration of synthetic OT 0.0116 mg/kg and antagonist atosiban (OTA) 1 mg/kg on food intake, and body weight of female mice, for different duration i.e. 30, 60, and 90 days. In this study, it was observed that there was significant decrease (p<0.001, one-way analysis of variance [ANOVA]) in the body weight (BW), food intake, and gonadosmatic indices (GSI) after the intraperitoneal exposure of OT at dose 0.0116 mg/kg up to 90 days and inhibits via antagonist atosiban. These results indicates that intraperitoneal administration of OT can be used for treatment for longer duration without any side effects and maintains homeostasis in physiologic system regulates body weight and gonadal weight in female mice, which represent an important therapeutic tool for the obesity and metabolic disorder in female.
越来越多的证据表明，催产素（OT）是控制人类和非人类动物食物摄入、体重及能量代谢的重要因素。此前有报道称，催产素受体（OTRs）表达下调与肥胖的发生有关，但外源性OT可使肥胖动物模型的体重和食物摄入量恢复正常。了解腹膜内给药是否能穿过血脑屏障很重要。因此，在本实验中，我们研究了腹膜内注射0.0116 mg/kg合成OT和1 mg/kg拮抗剂阿托西班（OTA），在不同时间段（即30天、60天和90天）对雌性小鼠食物摄入量和体重的影响。在本研究中，观察到腹膜内注射0.0116 mg/kg OT长达90天并通过拮抗剂阿托西班抑制后，体重（BW）、食物摄入量和性腺指数（GSI）显著下降（p<0.001，单因素方差分析[ANOVA]）。这些结果表明，腹膜内注射OT可长期用于治疗且无任何副作用，并维持生理系统的稳态，调节雌性小鼠的体重和性腺重量，这是治疗雌性肥胖和代谢紊乱的重要治疗手段。
