Qin Xiaojun, Yang Xingye, Du Lupei, Li Minyong
School of Pharmacy, Guangxi Medical University Nanning Guangxi 530021 China.
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University Jinan Shandong 250012 China
RSC Med Chem. 2021 Aug 9;12(11):1826-1838. doi: 10.1039/d1md00170a. eCollection 2021 Nov 17.
Local polarity can affect the physical or chemical behaviors of surrounding molecules, especially in organisms. Cell polarity is the ultimate feedback of cellular status and regulation mechanisms. Hence, the abnormal alteration of polarity in organisms is closely linked with functional disorders and many diseases. It is incredibly significant to monitor and detect local polarity to explain the biological processes and diagnoses of some diseases. Because of their safe and real-time monitoring, several polarity-sensitive fluorophores and fluorescent probes have gradually emerged and been used in modern research. This review summarizes the fluorescence properties and applications of several representative polarity-sensitive fluorescent probes.
局部极性会影响周围分子的物理或化学行为，在生物体中尤其如此。细胞极性是细胞状态和调节机制的最终反馈。因此，生物体中极性的异常改变与功能紊乱和许多疾病密切相关。监测和检测局部极性对于解释生物过程和某些疾病的诊断具有极其重要的意义。由于其安全且实时监测的特性，几种极性敏感荧光团和荧光探针逐渐出现并应用于现代研究中。本综述总结了几种代表性极性敏感荧光探针的荧光特性及应用。
