双相障碍患者的社会认知缺陷：系统评价和荟萃分析。
Deficits of social cognition in bipolar disorder: Systematic review and meta-analysis.
机构信息
Mood Disorder Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
出版信息
Bipolar Disord. 2022 Mar;24(2):137-148. doi: 10.1111/bdi.13163. Epub 2021 Dec 8.
BACKGROUND
The association between impaired social cognition and bipolar disorder (BD) is well established. However, to our knowledge, there has not been a recent systematic review that characterizes disparate dimensions of social cognition in BD. Herein, this systematic review and meta-analysis aimed to synthesize the literature on core aspects of social cognition (i.e., Theory of Mind, emotion recognition, and social judgment) to identify potential areas of impairment.
METHODS
Online databases (i.e., PubMed, Cochrane Libraries, PsycINFO) and Google Scholar were searched from inception to May 2021. Studies with populations ages ≥16 with DSM-IV or DSM-5 defined BD (I or II) either in a euthymic or symptomatic state were included. The risk of bias was measured using the ROBINS-1 tool, and the quality of the sources was evaluated using GRADE criteria. The results of the studies were quantitatively measured by synthesizing Hedge's g effect sizes through a random effects meta-analytic approach.
RESULTS
A total of 29 studies were included in the final review (i.e., 12 studies on the Theory of Mind, 11 on emotion recognition, and 6 on social judgment). Overall, results demonstrated social cognition to be moderately impaired in individuals with BD (d = 0.59). The individual domains ranged in effect size (0.38 < d < 0.70), providing evidence for variation in impairment within social cognition.
DISCUSSION
Individuals with BD exhibit clinically significant deficits in social cognition during euthymic and symptomatic states. Social cognition impairments in individuals with BD are an important therapeutic target for treatment discovery and development.
背景
社交认知障碍与双相情感障碍（BD）之间存在关联，这一点已得到充分证实。然而，据我们所知，最近还没有一项系统综述能够描述 BD 患者社交认知的不同维度。本系统综述和荟萃分析旨在综合有关社交认知核心方面的文献（即心理理论、情绪识别和社会判断），以确定潜在的受损领域。
方法
从建库开始至 2021 年 5 月，我们在线检索了数据库（PubMed、Cochrane 图书馆、PsycINFO）和 Google Scholar，纳入了符合 DSM-IV 或 DSM-5 定义的双相情感障碍（I 或 II 型）患者人群（年龄≥16 岁）的研究，这些患者无论在病情稳定期还是在症状期，均处于确诊状态。使用 ROBINS-1 工具评估偏倚风险，并使用 GRADE 标准评估来源的质量。通过随机效应荟萃分析方法，综合 Hedge's g 效应大小来定量测量研究结果。
结果
最终的综述共纳入了 29 项研究（即 12 项关于心理理论的研究、11 项关于情绪识别的研究和 6 项关于社会判断的研究）。总体而言，研究结果表明，BD 患者的社交认知能力存在中度损害（d=0.59）。各个领域的效应大小不同（0.38<d<0.70），这表明社交认知中的损害存在差异。
讨论
在病情稳定期和症状期，BD 患者均表现出明显的社交认知缺陷。BD 患者的社交认知障碍是治疗发现和发展的重要治疗靶点。
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