头颈部癌症放疗期间与 COVID-19 大流行期间患者报告的结局和并发症。
Patient-reported outcomes and complications during head and neck cancer radiotherapy before versus during the COVID-19 pandemic.
机构信息
BC Cancer - Vancouver Centre, 600 W 10th Ave, Vancouver, BC, V5K 4E6, Canada.
Univeristy of British Columbia, Vancouver, BC, Canada.
出版信息
Support Care Cancer. 2022 Mar;30(3):2745-2753. doi: 10.1007/s00520-021-06703-x. Epub 2021 Nov 26.
PURPOSE
This study compares patient-reported outcomes and treatment-related complications during radiotherapy before (August 2019-January 2020) versus during (March-Sept 2020) the COVID-19 pandemic.
MATERIALS AND METHODS
The MD Anderson Symptom Inventory-head and neck module was used to assess curative intent in H&N cancer patients' symptoms during radiotherapy.
RESULTS
There were 158 patients in the pre-pandemic cohort and 137 patients in the pandemic cohort. There was no significant difference in enteral feeding requirements between the cohorts (21% versus 30%, p = 0.07). Weight loss was higher during the pandemic (mean - 5.6% versus 6.8%, p = 0.03). On multivariate analysis, treatment during the pandemic was associated with higher symptom scores for coughing/choking while eating (2.7 versus 2.1, p = 0.013).
CONCLUSIONS
Complication rates during H&N radiotherapy during the COVID-19 pandemic were similar at our institution relative to the pre-pandemic era, although weight loss was greater and patients reported more severe choking/coughing while eating.
目的
本研究比较了 COVID-19 大流行前后（2019 年 8 月至 2020 年 1 月与 2020 年 3 月至 9 月）放疗期间患者报告的结局和与治疗相关的并发症。
材料和方法
使用 MD 安德森症状量表-头颈部模块评估头颈部癌症患者放疗期间的症状。
结果
大流行前队列有 158 例患者，大流行队列有 137 例患者。两组患者的肠内喂养需求无显著差异（21%比 30%，p=0.07）。大流行期间体重减轻更多（平均-5.6%比 6.8%，p=0.03）。多变量分析显示，大流行期间治疗与进食时咳嗽/哽噎的症状评分较高相关（2.7 比 2.1，p=0.013）。
结论
与大流行前相比，我们机构在 COVID-19 大流行期间头颈部放疗的并发症发生率相似，但体重减轻更多，患者报告进食时更严重的呛咳。
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