1st Propedeutic Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Department of Minimal Invasive Endocrine Surgery, Euromedica Kyanous Stavros, Thessaloniki, Greece.
J Endocrinol Invest. 2022 Apr;45(4):797-802. doi: 10.1007/s40618-021-01710-5. Epub 2021 Nov 26.
Parathyroidectomy (PTx) improves quality of life (QoL) in patients with primary hyperparathyroidism (PHPT). Whether this effect is modified according to the patients' age is unknown. The aim of this study was to evaluate the impact of age on the effect of PTx on QoL and frailty in patients with PHPT, six months post-PTx.
This was a prospective cohort study, including patients with PHPT, admitted from January 2016 to December 2019, divided into two categories: younger (≤ 65 years old) and older (> 65 years old). QoL was assessed with the Pasieka questionnaire (PAS-Q) two days pre- and six months post-operatively. Frailty was also assessed at the same time intervals, with the Frailty Index (FI).
One hundred and thirty-four patients (younger group: 96 patients, mean age 50.4 ± 9.8 years; older group: 38 patients, mean age 72.1 ± 4.9 years) were included. PTx resulted in a significant reduction in PAS-Q score in both groups. Notably, a greater reduction in "mood swings", "irritability", "itchy skin" and "feeling thirsty" PAS-Q domains was observed in the younger group. In contrast, a greater decrease in "bone pain", "tiredness", "weakness", "joint pain", "getting off chair" and "headaches" items was observed in the older group. Moreover, PTx led to a decrease in FI only in this group.
PTx leads to an improvement in QoL both in older (> 65 years) and younger (≤ 65 years) patients with PHPT, attributed to a differential effect on PAS-Q items. Frailty improves only in the older group.
甲状旁腺切除术（PTx）可改善原发性甲状旁腺功能亢进症（PHPT）患者的生活质量（QoL）。但目前尚不清楚这种效果是否会因患者年龄而改变。本研究旨在评估年龄对 PHPT 患者 PTx 后 6 个月 QoL 和虚弱的影响。
这是一项前瞻性队列研究，纳入 2016 年 1 月至 2019 年 12 月期间因 PHPT 入院的患者，分为年轻组（≤65 岁）和老年组（>65 岁）。术前和术后 6 个月分别采用帕西卡问卷（PAS-Q）评估 QoL。同时，在相同时间间隔内采用衰弱指数（FI）评估衰弱情况。
共纳入 134 例患者（年轻组 96 例，平均年龄 50.4±9.8 岁；老年组 38 例，平均年龄 72.1±4.9 岁）。两组患者的 PAS-Q 评分均显著降低。值得注意的是，年轻组患者的“情绪波动”、“易怒”、“皮肤瘙痒”和“口渴”等 PAS-Q 评分的降幅更大。相比之下，老年组患者的“骨痛”、“疲倦”、“虚弱”、“关节痛”、“从椅子上站起来”和“头痛”等评分的降幅更大。此外，只有老年组患者的 FI 降低。
PTx 可改善 PHPT 患者（包括老年组>65 岁和年轻组≤65 岁）的 QoL，这归因于 PAS-Q 评分的不同影响。仅在老年组患者中，虚弱情况得到改善。
