Department of Endocrine Surgery, General Surgery Service, Virgen de La Arrixaca University Hospital, Murcia, Spain.
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
World J Surg. 2023 Sep;47(9):2197-2205. doi: 10.1007/s00268-023-07066-6. Epub 2023 May 21.
Improvements in quality of life (QoL) after parathyroidectomy in patients with primary hyperparathyroidism (PHPT) is discussed. It has not been analyzed whether these improvements can be influenced by a specific socio-personal or clinical patient profile.
to analyze QoL differences after parathyroidectomy and to determine a socio-personal and clinical profile that influences improvement after parathyroidectomy.
A longitudinal prospective cohort study in patients with PHPT. SF-36 and PHPQOL questionnaires were completed by the patients. A comparative preoperatory analysis was carried out, at three and twelve months after surgery. Student's t test was used for the correlations. The size of the effect was assessed using G*Power software. A multivariate analysis was performed to evaluate the socio-personal and clinical variables affecting the improvement in QoL after surgery.
Forty-eight patients were analyzed. Three months after surgery an improvement was found in physical function, general health, vitality, social function, emotional role, mental health and in the patient's declared health assessment. One year after the intervention a general improvement was observed, with a greater effect on mental health and declared health evolution. Patients with bone pain presented with a higher probability of improvement after surgery. Patients with prior psychological disease had a lower associated probability of an improvement and high levels of PTH related to a greater probability of improvement after surgery.
There is an improvement in the QoL of PHPT patients after parathyroidectomy. Patients with bone pain and high PTH levels prior to the parathyroidectomy present with a greater probability of having a greater improvement in QoL after surgery.
甲状旁腺功能亢进症（PHPT）患者甲状旁腺切除术后生活质量（QoL）的改善情况备受关注。目前尚未分析这些改善是否可以受特定的社会个人或临床患者特征的影响。
分析甲状旁腺切除术后 QoL 的差异，并确定影响甲状旁腺切除术后改善的社会个人和临床特征。
对 PHPT 患者进行纵向前瞻性队列研究。患者完成 SF-36 和 PHPQOL 问卷。进行术前分析，在手术前、术后 3 个月和 12 个月进行比较。采用学生 t 检验进行相关性分析。使用 G*Power 软件评估效应大小。进行多变量分析，以评估影响术后 QoL 改善的社会个人和临床变量。
共分析了 48 例患者。术后 3 个月，患者的生理功能、总体健康状况、活力、社会功能、情感角色、心理健康和自我报告的健康评估均有所改善。术后 1 年观察到整体改善，心理健康和自我报告的健康演变效果更为明显。存在骨痛的患者术后更有可能改善。术前存在心理疾病的患者改善的可能性较低，甲状旁腺激素（PTH）水平较高与术后改善的可能性更大相关。
甲状旁腺切除术后 PHPT 患者的生活质量得到改善。术前存在骨痛和高 PTH 水平的患者术后生活质量改善的可能性更大。
