Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; Neuroscience Laboratory (Brain, Cognition and Behavior), Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Life Sci. 2022 Mar 1;292:120175. doi: 10.1016/j.lfs.2021.120175. Epub 2021 Nov 23.
Asthma is an airway inflammatory disease that is affected by neurological and psychological factors. The aim of present review is to investigating the relationship between neural functions and neurobiological changes and asthma symptoms.
The information in this article is provided from articles published in English and reputable database using appropriate keywords from 1970 to October 2020.
The symptoms of asthma such as cough, difficult breathing, and mucus secretion get worse when a person is suffering from stress, anxiety, and depression. The function of the insula, anterior cingulate cortex, and hypothalamic-pituitary-adrenal axis changes in response to stress and psychological disease; then the stress hormones are produced from neuroendocrine system, which leads to asthma exacerbation. The evidence represents that psychological therapies or neurological rehabilitation reduces the inflammation through modulating the activity of neurocircuitry and the function of brain centers involved in asthma. Moreover, the neurotrophins and neuropeptides are the key mediators in the neuro-immune interactions, which secrete from the airway nerves in response to brain signals, and they could be the target of many new therapies in asthma.
This review provides an insight into the vital role of the central and peripheral nervous system in development and exacerbation of asthma and provide practical approaches and strategies on neural networks to improve the airway inflammation and asthma severity.
哮喘是一种气道炎症性疾病，受神经和心理因素的影响。本综述的目的是研究神经功能和神经生物学变化与哮喘症状之间的关系。
本文的信息来源于 1970 年至 2020 年 10 月期间使用适当关键词在英文出版物和知名数据库中发表的文章。
当人们感到压力、焦虑和抑郁时，哮喘的症状（如咳嗽、呼吸困难和黏液分泌）会恶化。脑岛、前扣带皮层和下丘脑-垂体-肾上腺轴在应对压力和心理疾病时会发生功能改变；然后，神经内分泌系统会产生应激激素，导致哮喘恶化。有证据表明，心理疗法或神经康复通过调节神经回路的活性和参与哮喘的脑中枢的功能来减轻炎症。此外，神经生长因子和神经肽是神经-免疫相互作用的关键介质，它们会根据大脑信号从气道神经中分泌出来，它们可能成为哮喘许多新疗法的靶点。
本综述深入了解了中枢和外周神经系统在哮喘发展和恶化中的重要作用，并提供了关于神经网络的实用方法和策略，以改善气道炎症和哮喘严重程度。
