Vig Rattanjeet S, Forsythe Paul, Vliagoftis Harissios
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.
Ann N Y Acad Sci. 2006 Nov;1088:65-77. doi: 10.1196/annals.1366.023.
Asthma, a chronic inflammatory disease of the airways, is greatly influenced by psychosocial factors and stress. This review looks at clinical studies that have shown strong associations between psychological stress and asthma to identify potential mechanisms for these interactions. Furthermore, we review animal studies involving stress and airway inflammation or airway hyperresponsiveness, and discuss possible mechanisms of stress action in asthma. In conclusion, further research, both in humans and in animal models, into the mechanisms of stress-induced changes in asthma exacerbation are required to help better understand the complex makeup of asthma and assist in the development of therapies directed at the interplay between the nervous system and airway inflammation.
哮喘是一种气道慢性炎症性疾病，受心理社会因素和压力的影响很大。本综述审视了一些临床研究，这些研究表明心理压力与哮喘之间存在密切关联，以确定这些相互作用的潜在机制。此外，我们回顾了涉及压力与气道炎症或气道高反应性的动物研究，并讨论了压力在哮喘中起作用的可能机制。总之，需要在人类和动物模型中进一步研究压力诱发哮喘加重的机制，以更好地理解哮喘的复杂构成，并有助于开发针对神经系统与气道炎症相互作用的治疗方法。
