Yang Jian-Hui, Strodl Esben, Wu Chuan-An, Yin Xiao-Na, Wen Guo-Min, Sun Deng-Li, Xian Dan-Xia, Chen Jing-Yi, Chen Ying-Jie, Chen Jing, Chen Wei-Qing
Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
School of Psychology and Counselling, Queensland University of Technology, Brisbane, QLD, Australia.
J Psychosom Res. 2021 Nov 19;152:110680. doi: 10.1016/j.jpsychores.2021.110680.
Few studies have evaluated the association between children's exposure to environmental tobacco smoke (ETS) in early life (during pregnancy, from birth to one year and from one to three years) and autistic-like behaviors. This study aimed to explore this association.
This cross-sectional study analyzed data collected in 2017 as part of the Longhua Child Cohort Study. Autistic-like behaviors were measured using the Autism Behavior Checklist (ABC). Data on ETS exposure and autistic-like behaviors of children were collected via self-administered questionnaires completed by the mothers. Multivariate logistic regression models were undertaken to assess the associations.
Of the 65,243 participants included in this study, 1958 children met criteria for having autistic-like behaviors. The results showed that children were more likely to exhibit autistic-like behaviors when they were exposed to ETS in early life (AOR = 1.38; 95% CI = 1.26-1.52), compared to preschoolers without ETS exposure at any period of their early life. Compared with their unexposed counterparts, children who were exposed to ETS during gestation (AOR = 1.42; 95% CI = 1.29-1.57), or from birth to one year old (AOR = 1.42; 95% CI = 1.19-1.69) had significantly increased risk of autistic-like behaviors. In addition, with the increase in duration of exposure and average number of cigarettes smoked in the child's immediate environment, the risk of autistic-like behaviors increased.
Our study indicated that children's ETS exposure in early life was significantly associated with autistic-like behaviors. When children's exposure to cigarettes in early life increased in duration and number, the likelihood of the presence of autistic-like behaviors was higher.
很少有研究评估儿童在生命早期（孕期、出生至一岁以及一岁至三岁）接触环境烟草烟雾（ETS）与类自闭症行为之间的关联。本研究旨在探究这种关联。
这项横断面研究分析了2017年作为龙华儿童队列研究一部分收集的数据。使用自闭症行为量表（ABC）测量类自闭症行为。通过母亲填写的自填问卷收集儿童ETS暴露和类自闭症行为的数据。采用多因素逻辑回归模型评估关联。
本研究纳入的65243名参与者中，1958名儿童符合类自闭症行为标准。结果显示，与生命早期任何时期均未接触ETS的学龄前儿童相比，儿童在生命早期接触ETS时更有可能表现出类自闭症行为（比值比[AOR]=1.38；95%置信区间[CI]=1.26 - 1.52）。与未接触者相比，孕期接触ETS的儿童（AOR = 1.42；95% CI = 1.29 - 1.57），或出生至一岁时接触ETS的儿童（AOR = 1.42；95% CI = 1.19 - 1.69）出现类自闭症行为的风险显著增加。此外，随着接触持续时间的增加以及儿童直接环境中平均吸烟数量的增加，类自闭症行为的风险增加。
我们的研究表明，儿童在生命早期接触ETS与类自闭症行为显著相关。当儿童在生命早期接触香烟的时间和数量增加时，出现类自闭症行为的可能性更高。
