School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China; Sate Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, China.
Phytochemistry. 2022 Feb;194:113019. doi: 10.1016/j.phytochem.2021.113019. Epub 2021 Nov 23.
During our continuous investigation of natural, herbal inhibitors of microglial over-activation in the Euphorbiaceae family, two plants of the Vernicia genus showed remarkable inhibitory effects on nitric oxide (NO) production in over-activated microglia. In this study, bioactivity-guided phytochemical research on the active fraction of the roots of V. montana was carried out. As a result, seven undescribed terpenoids and lignans, together with thirty-one known components, were isolated and identified using comprehensive spectral analysis. All the identified compounds were evaluated for their inhibitory effects on NO production in lipopolysaccharide-stimulated BV-2 cells. Combined with our previous research on the Vernicia genus, the effective material basis of different plants and medicinal components was analyzed systematically.
在我们对大戟科天然、草药类抑制小胶质细胞过度激活物质的持续研究中，山桐子属的两种植物对激活小胶质细胞中一氧化氮（NO）的产生表现出显著的抑制作用。在这项研究中，对显脉山桐子根的活性部分进行了基于生物活性的植物化学研究。结果，利用综合光谱分析从该活性部分分离鉴定了 7 个未被描述的萜类化合物和木脂素，以及 31 个已知成分。所有鉴定的化合物都进行了评估，以检测它们对脂多糖刺激的 BV-2 细胞中 NO 产生的抑制作用。结合我们之前对山桐子属的研究，对不同植物和药用成分的有效物质基础进行了系统分析。
