Jansåker Filip, Li Xinjun, Knudsen Jenny Dahl, Milos Nymberg Veronica, Sundquist Kristina
Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, 205 02 Malmö, Sweden.
Department of Clinical Microbiology, Rigshospitalet, Copenhagen University, 2100 Copenhagen, Denmark.
Antibiotics (Basel). 2021 Nov 12;10(11):1389. doi: 10.3390/antibiotics10111389.
Uncomplicated cystitis is one of the most common reasons for antibiotic treatment in otherwise healthy women. Nationwide studies on antibiotic treatment for this infection and in relation to factors beyond the infection itself have hitherto not been available.
This was a nationwide open cohort study consisting of 352,507 women aged 15-50 years with uncomplicated cystitis (2006-2018). The outcome was a redeemed antibiotic prescription within five days from the cystitis diagnosis. Logistic regression models were used to examine the relationship between the outcome and the predictor variables.
This study identified 192,065 redeemed treatments (54.5%). Several sociodemographic variables were associated with antibiotic treatment. For example, women with the lowest income had an odds ratio (OR) of 1.26 (95% CI 1.23-1.28) compared to those with the highest income. History of cervical cancer and high parity were also associated with lower treatment rates.
This study presents novel factors beyond the infection which seem to affect the antibiotic treatment for uncomplicated cystitis in women. Future studies to investigate possible mechanisms are warranted in order to properly use our findings. This may help healthcare workers and planners to provide a more equal treatment plan for this common infection, which may reduce misuse of antibiotics, decrease costs and improve efforts against antibiotic resistance.
单纯性膀胱炎是健康女性接受抗生素治疗的最常见原因之一。迄今为止，尚未有关于这种感染的抗生素治疗以及与感染本身之外的因素相关的全国性研究。
这是一项全国性的开放队列研究，由352507名年龄在15至50岁之间患有单纯性膀胱炎的女性组成（2006年至2018年）。研究结果是膀胱炎诊断后五天内兑现的抗生素处方。使用逻辑回归模型来检验结果与预测变量之间的关系。
本研究确定了192065例已兑现的治疗（54.5%）。几个社会人口统计学变量与抗生素治疗有关。例如，收入最低的女性与收入最高的女性相比，比值比（OR）为1.26（95%CI 1.23-1.28）。宫颈癌病史和多产也与较低的治疗率有关。
本研究提出了感染之外的新因素，这些因素似乎会影响女性单纯性膀胱炎的抗生素治疗。有必要进行进一步的研究来探究可能的机制，以便正确运用我们的研究结果。这可能有助于医护人员和规划者为这种常见感染提供更平等的治疗方案，从而减少抗生素的滥用，降低成本，并加强对抗生素耐药性的应对措施。
