Sobczak Anna Maria, Bohaterewicz Bartosz, Fafrowicz Magdalena, Domagalik Aleksandra, Beldzik Ewa, Oginska Halszka, Golonka Natalia, Rekas Marek, Bronicki Dominik, Romanowska-Dixon Bożena, Bolsega-Pacud Joanna, Karwowski Waldemar, Farahani Farzad V, Marek Tadeusz
Department of Cognitive Neuroscience and Neuroergonomics, Institute of Applied Psychology, Jagiellonian University, 30-348 Kraków, Poland.
Malopolska Centre of Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Brain Sci. 2021 Oct 24;11(11):1400. doi: 10.3390/brainsci11111400.
Cataract is one of the most common age-related vision deteriorations, leading to opacification of the lens and therefore visual impairment as well as blindness. Both cataract extraction and the implantation of blue light filtering lens are believed to improve not only vision but also overall functioning.
Thirty-four cataract patients were subject to resting-state functional magnetic resonance imaging before and after cataract extraction and intraocular lens implantation (IOL). Global and local graph metrics were calculated in order to investigate the reorganization of functional network architecture associated with alterations in blue light transmittance. Psychomotor vigilance task (PVT) was conducted.
Graph theory-based analysis revealed decreased eigenvector centrality after the cataract extraction and IOL replacement in inferior occipital gyrus, superior parietal gyrus and many cerebellum regions as well as increased clustering coefficient in superior and inferior parietal gyrus, middle temporal gyrus and various cerebellum regions. PVT results revealed significant change between experimental sessions as patients responded faster after IOL replacement. Moreover, a few regions were correlated with the difference in blue light transmittance and the time reaction in PVT.
Current study revealed substantial functional network architecture reorganization associated with cataract extraction and alteration in blue light transmittance.
白内障是最常见的与年龄相关的视力衰退之一，会导致晶状体混浊，进而造成视力损害甚至失明。白内障摘除术和蓝光滤过型人工晶状体植入术都被认为不仅能改善视力，还能提升整体功能。
34名白内障患者在白内障摘除及人工晶状体植入（IOL）前后接受静息态功能磁共振成像检查。计算全局和局部图指标，以研究与蓝光透过率改变相关的功能网络结构重组情况。进行了精神运动警觉任务（PVT）。
基于图论的分析显示，白内障摘除及IOL置换后，枕下回、顶上小叶和多个小脑区域的特征向量中心性降低，而顶上小叶、颞中回和多个小脑区域的聚类系数增加。PVT结果显示，实验阶段之间存在显著变化，患者在IOL置换后反应更快。此外，一些区域与蓝光透过率差异和PVT中的时间反应相关。
当前研究揭示了与白内障摘除及蓝光透过率改变相关的显著功能网络结构重组。
