Lo Wai-Leung Ambrose, Chen Dandan, Zhao Jiangli, Leng Yan, Bian Ruihao, Huang Wenzhu, Liang Yahui, Mao Yu-Rong, Huang Dong-Feng
Guangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, Sun Yat-sen University, Guangzhou 510080, China.
Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Brain Sci. 2021 Nov 12;11(11):1495. doi: 10.3390/brainsci11111495.
The efficacy of interlimb-coordinated training on gait and upper limb functional improvement remains unclear. The latest published randomized controlled trials have supported the potential benefits of interlimb-coordinated training to enhance gait function. Upper limb functional recovery may also benefit from interlimb-coordinated training since most everyday activities require the coordinated use of both hands to complete a task. This study investigates the efficacy of interlimb-coordinated training on gait and upper limb functional recovery over a short-medium term period.
A total of 226 acute stroke patients will be recruited from four centres over four years. Patients will be randomly allocated to either conventional therapy or conventional therapy plus interlimb-coordinated training. Outcomes will be recorded at baseline, after 2 weeks of intervention, and at 3- and 6-months post-intervention. Gait speed is the primary outcome measure. Secondary outcome measures include Fugl-Meyer Assessment of Motor Recovery, Berg Balance Scale, Timed Up and Go test, Action Research Arm Test, electroencephalography, and magnetic resonance imaging.
The results of this trial will provide an in-depth understanding of the efficacy of early interlimb-coordinated intervention on gait and upper functional rehabilitation and how it may relate to the neural plasticity process.
肢体协调训练对步态和上肢功能改善的疗效尚不清楚。最新发表的随机对照试验支持了肢体协调训练对增强步态功能的潜在益处。由于大多数日常活动都需要双手协同使用来完成任务，上肢功能恢复也可能受益于肢体协调训练。本研究调查了肢体协调训练在中短期内对步态和上肢功能恢复的疗效。
将在四年内从四个中心招募总共226名急性中风患者。患者将被随机分配到常规治疗组或常规治疗加肢体协调训练组。将在基线、干预2周后以及干预后3个月和6个月记录结果。步态速度是主要结局指标。次要结局指标包括Fugl-Meyer运动恢复评估、伯格平衡量表、定时起立行走测试、动作研究臂测试、脑电图和磁共振成像。
本试验结果将深入了解早期肢体协调干预对步态和上肢功能康复的疗效，以及它与神经可塑性过程的关系。
