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Biomolecules. 2021 Jun 24;11(7):940. doi: 10.3390/biom11070940.
3
Inhibition of Glycine Re-Uptake: A Potential Approach for Treating Pain by Augmenting Glycine-Mediated Spinal Neurotransmission and Blunting Central Nociceptive Signaling.抑制甘氨酸再摄取：通过增强甘氨酸介导的脊髓神经传递和削弱中枢痛觉信号来治疗疼痛的一种潜在方法。
Biomolecules. 2021 Jun 10;11(6):864. doi: 10.3390/biom11060864.
4
Modulation of Glycinergic Neurotransmission may Contribute to the Analgesic Effects of Propacetamol.甘氨酸能神经传递的调制可能有助于丙帕他莫的镇痛作用。
Biomolecules. 2021 Mar 25;11(4):493. doi: 10.3390/biom11040493.
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A System for Assessing Dual Action Modulators of Glycine Transporters and Glycine Receptors.一种评估甘氨酸转运体和甘氨酸受体双重作用调节剂的系统。
Biomolecules. 2020 Nov 30;10(12):1618. doi: 10.3390/biom10121618.
6
Mutations affecting glycinergic neurotransmission in hyperekplexia increase pain sensitivity.影响肌阵挛性张力障碍中甘氨酸能神经传递的突变会增加疼痛敏感性。
Brain. 2018 Jan 1;141(1):63-71. doi: 10.1093/brain/awx289.
7
Glycine receptors and glycine transporters: targets for novel analgesics?甘氨酸受体和甘氨酸转运体：新型镇痛药的作用靶点？
Cell Mol Life Sci. 2018 Feb;75(3):447-465. doi: 10.1007/s00018-017-2622-x. Epub 2017 Aug 8.
8
Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain.甘氨酸转运体作为精神分裂症、酒精依赖和疼痛的新型治疗靶点。
Nat Rev Drug Discov. 2013 Nov;12(11):866-85. doi: 10.1038/nrd3893.
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GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.甘氨酸受体α3：脊髓中前列腺素E2介导的炎性疼痛敏化的关键靶点。
Science. 2004 May 7;304(5672):884-7. doi: 10.1126/science.1094925.

甘氨酸转运体和受体作为镇痛药的作用靶点。

Glycine Transporters and Receptors as Targets for Analgesics.

机构信息

School of Health and Behavioural Sciences, University of the Sunshine Coast, Maroochydore, QLD 4556, Australia.

Sunshine Coast Health Institute, Birtinya, QLD 4558, Australia.

出版信息

Biomolecules. 2021 Nov 11;11(11):1676. doi: 10.3390/biom11111676.

DOI:10.3390/biom11111676
PMID:34827674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8615606/
Abstract

The suitability of modulating glycinergic neurotransmission for the treatment of inflammatory and chronic pain has gained widespread recognition, with glycine receptors (GlyRs) and glycine transporters (GlyT1 and GlyT2) now considered key therapeutic targets [...].

摘要

调节甘氨酸能神经传递对于治疗炎症和慢性疼痛的适用性已经得到广泛认可，甘氨酸受体（GlyRs）和甘氨酸转运体（GlyT1 和 GlyT2）现在被认为是关键的治疗靶点[...]。