Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Department of Animal Sciences, State University of Ponta Grossa, Ponta Grossa 84030-900, Brazil.
Genes (Basel). 2021 Nov 19;12(11):1830. doi: 10.3390/genes12111830.
Lactation persistency and milk production are among the most economically important traits in the dairy industry. In this study, we explored the association of over 6.1 million imputed whole-genome sequence variants with lactation persistency (LP), milk yield (MILK), fat yield (FAT), fat percentage (FAT%), protein yield (PROT), and protein percentage (PROT%) in North American Holstein cattle. We identified 49, 3991, 2607, 4459, 805, and 5519 SNPs significantly associated with LP, MILK, FAT, FAT%, PROT, and PROT%, respectively. Various known associations were confirmed while several novel candidate genes were also revealed, including , , , , , , , , , , and for LP; , , , , , and for MILK; , , , POL, , and for FAT; , , and the KCN gene family for FAT%; , , , and for PROT; and , , , , and for PROT%. Most of these genes are involved in relevant gene ontology (GO) terms such as fatty acid homeostasis, transporter regulator activity, response to progesterone and estradiol, response to steroid hormones, and lactation. The significant genomic regions found contribute to a better understanding of the molecular mechanisms related to LP and milk production in North American Holstein cattle.
泌乳持久力和产奶量是奶牛养殖业中最重要的经济性状之一。在这项研究中，我们探索了超过 610 万个全基因组序列变异与泌乳持久力（LP）、产奶量（MILK）、脂肪产量（FAT）、脂肪百分比（FAT%）、蛋白质产量（PROT）和蛋白质百分比（PROT%）之间的关联。我们鉴定了 49 个、3991 个、2607 个、4459 个、805 个和 5519 个 SNP 与 LP、MILK、FAT、FAT%、PROT 和 PROT%显著相关。我们确认了各种已知的关联，同时还揭示了一些新的候选基因，包括、、、、、、、、、和 与 LP 相关；、、、、、和 与 MILK 相关；、、、POL、、和 与 FAT 相关；、、、和 与 FAT%相关；、、、和 与 PROT 相关；和、、、、和 与 PROT%相关。这些基因大多参与了相关的基因本体（GO）术语，如脂肪酸稳态、转运体调节剂活性、对孕激素和雌二醇的反应、对类固醇激素的反应和泌乳。发现的显著基因组区域有助于更好地理解与北美荷斯坦奶牛泌乳持久力和产奶量相关的分子机制。
