Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Québec-Université Laval Research Center, Québec, QC G1V 4G2, Canada.
Department of Molecular Medicine, Faculty of Medicine, Laval University, Québec, QC G1V 0A6, Canada.
Genes (Basel). 2021 Nov 20;12(11):1832. doi: 10.3390/genes12111832.
The numerous exercise benefits for health as well as applications for diseases has lead to exercise being prescribed in many pathological conditions. Secreted protein acidic and rich in cysteine (SPARC) gene expression is stimulated by exercise and SPARC has been suggested as a molecular mediator of exercise. Therefore, we suggest using this property for personalized medicine. This can be achieved by prescribing the exercise with a pattern (duration, intensity, etc.) that corresponds to the optimum expression. We expect this approach to optimize the exercise therapy in both the preventive and curative contexts. In the research field, measuring exercise -dependent expression of would represent a molecular tool to further optimize the selection of exercise animal models as well.
运动对健康的诸多益处以及在疾病中的应用使得运动在许多病理情况下都被规定为一种治疗方法。运动刺激分泌富含半胱氨酸的酸性蛋白（SPARC）基因表达，并且 SPARC 已被提议作为运动的分子介质。因此，我们建议将这种特性用于个性化医学。可以通过规定与最佳表达相对应的运动模式（持续时间、强度等）来实现这一点。我们期望这种方法能够优化预防和治疗两方面的运动疗法。在研究领域，测量运动依赖性的表达将成为一种分子工具，进一步优化运动动物模型的选择。
